中文摘要：

蛋白酪氨酸磷酸酶（protein tyrosine phos-phates,PTPs）是调节胰岛素信号转导的关键酶。PTPs通过对胰岛素受体和胰岛素受体底物蛋白磷酸化和去磷酸化调控胰岛素信号转导。PTPs抑制剂是潜在的治疗糖尿病和肥胖症的靶点药物,可以延长胰岛素信号的转导,加速葡萄糖的吸收,使血糖降低。本文主要概述PTPs在胰岛素信号转导通路中的作用及其作为新的治疗糖尿病药物靶点的研究进展。

英文摘要：

Protein tyrosine phosphates（PTPs） are key regulators of the insulin receptor signal transduction pathway.Insulin signaling is tightly regulated by the balance of IR tyrosine phosphorylation and dephosphorylating.Several PTPs expressed in the major human insulin target tissues or cells and could attenuate insulin action by dephosphorylating the IR.Inhibiting several PTPs would prolong insulin signaling and facilitate glucose uptake and decrease blood glucose.Inhibitors of several PTPs are predicted to be the novel drug targets for type 2 diabetes and obesity treatment.