中文摘要：

全基因组关联研究（GWAS）使用高通量的基因检测技术分析成百上千个遗传标记（基因型）与临床疾病和可测性状（表型）的相关性。2型糖尿病是环境和遗传因素共同作用的结果，GWAS在2型糖尿病的研究方面取得了重要进展，发现了涉及胰岛β细胞发育和功能的新的基因区域，为2型糖尿病的病因学研究及防治提供新的思路。

英文摘要：

Genome-wide association studies （GWAS）use high-throughout genotyping technologies to investigate the relation of hundreds of thousands of gene markers（genotype）with clinical conditions and measurable traits （phenotype）. Type 2 diabetes mellitus results from the interaction of environmental factors with genetic variants. Many progresses have been acquired from GWAS. New gene regions have been discovered to be involved in the development and function of islet β-cells, which provides new strategies for the etiology investigation, prevention,and treatment of type 2 diabetes mellitus.