中文摘要：

为了避免或减少脊柱外科手术中过度牵拉神经根造成的医源性神经功能损伤,将硅压阻式压力传感器应用于手术器械神经拉勾上来量化术中对神经根的牵拉程度,以提高脊柱疾病的手术治疗成功率。在神经拉钩接触神经根的部位安装压力传感器,测量神经根被牵拉时所受压力。利用白兔和山羊进行不同程度和时间的神经根牵拉实验,并同时用肌电图监测不同牵拉情况下神经根电生理反应的变化。牵拉平均压力变化约14kPa时,潜伏期变化率为1.12%,波幅变化率为21.21%,表明被牵拉神经根的轴索部位有损伤;牵拉平均压力基本相同时,牵拉持续时间越长,神经根功能受损程度越大。牵拉的时间和加载在神经根上的压力与神经功能损伤程度正相关,表明通过实验建立了神经根所受压力与相应电生理反应的联系,有助于在今后的研究中进一步明确神经根牵拉的安全阈值。

英文摘要：

For reducing or avoiding the iatrogenic nerve function injury due to the excessive retraction for a nerve root during a spine surgery,a silicon piezoresistive pressure sensor was employed in the nerve root retractor to quantitate the retraction for the nerve root and to improve the performance of spine surgery.To measure the pressure exerted upon the retracted nerve root,a pressure sensor was adhered to the nerve engagement surface of a nerve retractor.The rabbit and goat experiments were performed on nerve root retraction by different time durations and pressure extendings,while the nerve function injury was assessed by monitoring the electromyogram responses.Experiments show when the increase of average pressure is about 14 kPa,the change rates of latency and amplitude are 1.12% and 21.21%,respectively,which reveals that the retracted nerve root axonal is damaged.Furthermore,loading similar average pressare,the more the retraction time applies to the nerve root,the worse the nerve function is hurt.In conclusion,the relationship between the pressure exerted on the nerve root and the corresponding neuromuscular responses has been founded via the results of animal experiments,which shows the degree of nerve root impairment is positively correlated with the duration and extent of nerve root retraction,and can be used in the study of retraction threshold values.