中文摘要：

为了研究铅、镉单独或联合慢性暴露引起SD大鼠的氧化损伤和肾脏组织结构变化,以及抗氧化剂乙酰半胱氨酸(NAC)对其的保护作用,用不同剂量的铅、镉连续灌服大鼠4周后,测定肾脏和血浆SOD、GSH-Px活性及脂质过氧化主要终产物MDA含量,并用光学显微镜观察肾脏组织学变化。结果显示,与对照组比较,铅、镉单独染毒肾脏和血浆SOD、GSH-Px活性及MDA含量均显著升高(P<0.05);铅、镉联合染毒血浆和肾脏SOD、GSH-Px的活性较对照组显著下降(P<0.05),MDA含量显著升高(P<0.05);添加NAC组与铅、镉联合染毒组相比GSH-Px活性显著升高(P<0.05),MDA含量显著下降(P<0.05)。组织切片观察显示,铅、镉单独或联合染毒均导致肾小管管腔内蛋白渗出,管腔变窄甚至闭合,肾小管上皮细胞肿胀、浑浊等病变。由此可见,机体脂质过氧化作用增强是铅、镉引起机体损伤的主要机制之一,可能也是铅、镉引起肾脏组织病变的原因之一。NAC能有效缓解铅、镉引起的氧化损伤,但对肾脏组织病变无明显的保护作用。

英文摘要：

In order to evaluate the oxidative damage and pathologic lesion in kidney induced by chronic lead(Pb) and cadmium(Cd) exposure to SD rats respectively or combined,and antioxidant N-acetylcysteine′s(NAC) protective effects,different doses of Pb and Cd were orally administrated for four weeks succesively.The activities of SOD、GSH-Px and MDA content was measured,and histological structure of kidney was observed.The results showed that the activities of SOD、GSH-Px and MDA content both increased significantly(P&...