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烷基杂环芳基二硫醚类化合物的合成及抗癌活性研究
  • ISSN号：0253-2786
  • 期刊名称：《有机化学》
  • 分类：O627.42[理学—有机化学;理学—化学]
  • 作者机构：[1]中国科学院上海药物研究所新药研究国家重点实验室,上海201203
  • 相关基金：国家新药创制重大专项（No.2009ZX09301-00 2009ZX09103-060）; 国家自然科学基金（Nos.81072572 21072204 21021063）; 国家海洋“863”计划（No.2011AA09070102）; 上海市科委基础研究（Nos.09ZR1438000 10540702900）; 中国科学院重点（Nos.KSCX2-EW-R-15 KSCX2-YW-R-18）资助项目
作者： 龚景旭[1], 盛丽[1], 姚励功[1], 李佳[1], 周宇波[1], 郭跃伟[1]
关键词： 二硫醚, 合成, 抗肿瘤活性, disulfides, synthesis, anti-tumor activity
中文摘要：

通过Bunte盐与杂环芳基硫醇反应,得到了一系列的烷基芳基二硫醚类化合物.得到的全部二硫醚类化合物对人结肠癌细胞HCT-116抑制活性进行了体外评价,发现所有化合物具有明显的体外抗肿瘤活性,其半抑制浓度IC50为4.8～17.7μg mL^-1.

英文摘要：

A series of alkyl heterocyclyl disulfides were prepared by reaction of the heterocyclyl thiol with Bunte salts.All the synthesized compounds showed interesting inhibit activities toward human colon carcinoma cells（HCT-116） in vitro.The IC50values of the tested compounds ranged from 4.8 μg mL^-1to 17.7 μg mL^-1.

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期刊信息
  • 《有机化学》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:中国化学会 中国科学院上海有机化学研究所
  • 主编：陈庆云
  • 地址：上海市枫林路354号
  • 邮编：200032
  • 邮箱：bianji@mail.sioc.ac.cn
  • 电话：021-54925244
  • 国际标准刊号：ISSN：0253-2786
  • 国内统一刊号：ISSN：31-1321/O6
  • 邮发代号:4-285
  • 获奖情况:
  • 中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:14408