东篱科研大数据发现系统（DRDS）

位置：成果数据库 > 期刊 > 期刊详情页

Structural and functional characterization of the interaction of the photosensitizing probe methylen

ISSN号：0961-8368
期刊名称：Protein Science
时间：2012
页码：1138-1152
相关项目：药物作用新靶标、新机制和新分子实体发现方法与应用研究

同期刊论文项目

药物作用新靶标、新机制和新分子实体发现方法与应用研究

期刊论文 129

同项目期刊论文

Diastereoselective Michael Reaction of Chiral Nickel(II) Glycinate with Nitroalkenes for Asymmetric

The high affinity of hydroxamate-based MMP-12 inhibitors is due to an inherently slow dissociation o

Identification of Benzofuran-3-yl(phenyl)methanones as Novel SIRT1 Inhibitors: Binding Mode, Inhibit

Structural Switchings Of Staphylococcus Aureus ClpP: A Key To Understanding Protease Mechanism

Identification of N'-(2-oxoindolin-3-ylidene) hydrazide derivatives as c-Met Kinase Inhibitors

The Nature and Magnitude of Specific Halogen Bonds between Iodo-perfluorobenzene and Heterocyclic Sy

Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a M

Palmarumycins BG1-BG7 and Preussomerin BG1: Establishment of Their Absolute Configurations Using The

Lewis Acid-Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis o

Rhodium-Catalyzed Highly Enantioselective 1,2-Addition of Arylboronic Acids to α-Ketoesters an

Discovering potent inhibitors against c-Met kinase: focused library design, synthesis and bioassay

Highly Diastereoselective Friedel-Crafts Reaction of Arenes with N-tert-Butanesulfinylimino Ester to

Design of Chiral Sulfoxide-Olefins as a New Class of Sulfur-Based Olefin Ligands for Asymmetric Cata

Design of N-Sulfinyl Homoallylic Amines as Novel Sulfinamide-Olefin Hybrid Ligands for Asymmetric Ca

SmI2-Promoted Imino-Reformatsky Reaction for Facile Synthesis of Enantioenriched β-Amino Esters

Conformational transition and energy landscape of ErbB4 activated by neuregulin1β: one microsec

A Theoretical Model for Calculating Voltage Sensitivity of Ion Channels and the Application on Kv1.2

Theoretical and crystallographic data investigations of noncovalent S···O inter

Diterpenes from the Hainan Soft Coral Lobophytum cristatum Tixier-Durivault

Epipolythiodioxopiperazines from Fungi: Chemistry and Bioactivities

Recent advances in the gold-catalyzed additions to C–C multiple bonds

Synthesis of Pyrrolo[1,2-a]quinoxalines via Gold(I)-Mediated Cascade Reactions

Silver- and Gold-Mediated Domino Transformation: A Strategy for SynthesizingBenzo[e]indolo[1,2-a]pyr

Enantioselective Synthesis of Chiral 3-Aryl-1-indanones through Rhodium-Catalyzed Asymmetric Intramo

“Simple Branched Sulfur-Olefins as Chiral Ligands for Rh-Catalyzed Asymmetric Arylation of Cyc

Preparation of α-Alkyl-β-Amino Acids via β-Alanine Ni(II) Complex

Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp proteas

Efficient Synthesis of Optically Active α-Quaternary Amino Acids by Highly Diastereoselective

Design of N-Cinnamyl Sulfinamides as New Sulfur-Containing Olefin Ligands for Asymmetric Catalysis:

Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation Using Unsymmetrical Vicinal Diamine-Based

Paracaseolide A, First r-Alkylbutenolide Dimer with an Unusual Tetraquinane Oxa-Cage Bislactone Skel

9’-Epi-3?,3’?-dimethylxestospongin C, A New Macrocyclic Diamine Alkaloid from the Hainan

Synthesis of 4-Aryl-2(5H)-furanones by Gold(I)-Catalyzed Intramolecular Annulation.

Development of Cell-Active N(6)-Methyladenosine RNA Demethylase FTO Inhibitor

Chiral Sulfinamide-Olefin Ligands: Switchable Selectivity in Rhodium-Catalyzed Asymmetric 1,2-Additi

Absolute Stereochemistry of Integracins A, B and 15'-Dehydroxy-integracin B

Biscembranoids Formed from an α,β-Unsaturated γ-Lactone Ring as a Dienophile: Struc

Design and Synthesis of Polymeric Chiral Bicyclo[3.3.0] Diene as Reusable Ligand for Rhodium-Catalyz

Zn-Mediated Asymmetic Allylation of N-tert-Butanesulfinyl Ketimines: An Efficient and Practical Acce

Lewis Acid-Catalyzed Intramolecular Aza-Friedel-Crafts Reaction of N-tert-Butanesulfinyl Imines: Eff

Rh-catalyzed Enantioselective 1,2-Addition to Unsymmetrical α-Diketones: Tandem One-Pot Synthe

肉芝软珊瑚属中二聚西松烷型二萜化合物的化学和生物活性研究进展

Structure-based computational study of the hydrolysis of New Delhi metallo-beta-lactmase-1.

Asymmetric Michael Addition of N-tert-Butanesulfinyl Imidates: an Efficient Strategy for the Synthes

Highly diastereo- and enantioselective synthesis of syn-β-substituted tryptophans via asymmetri

Discovery of potent small molecule inhibitors of DYRK1A by structure-based virtual screening and bio

The essential role for aromatic cluster in the β3 adrenergic receptor

Assignment of Absolute Configuration of Bis-?-pyrone Polypropionates from Marine Pulmonate Mollusks

Structures and Absolute Stereochemistries of Nortriterpenoids from Schisandra chinensis (Turcz.) Bai

Synthesis and Biological Evaluation of 21-Arylidenepregnenolone Derivatives as Neuroprotective Agent

Phragmalin Limonoids from Chukrasia tabularis var

Disulfide- and Multisulfide-Containing Metabolites from Marine Organisms.

Improved Synthesis of Rupintrivir

Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphod

Identification and synthesis of N-(thiophen-2-yI) benzamide derivatives as BRAF(V600E) inhibitors

The stabilization effect of dielectric constant and acidic amino acids on arginine-arginine (Arg-Arg

Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labe

Key targets and relevant inhibitors for the drug discovery of tuberculosis

Dongxiang Liu*. Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: bindi

Unprecedented Diterpenoids as a PTP1B Inhibitor from the Hainan Soft Coral Sarcophyton trocheliophor

Virtual Screening and Structure-based discovery Indole Acylguanidines as Potent β-secretase (BA

The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a

Cembrane Diterpenoids from the Soft Coral Sarcophyton trocheliophorum Marenzeller as a New Class of

Asymmetric One-Pot Sequential Mannich/Hydroamination Reaction by Organo- and Gold Catalysts: Synthes

Structure-Based Design, Synthesis of C-1 and C-4 modified analogs of zanamivir as neuraminidase inhi

Design, synthesis, structure-activity relationships, and docking studies of 1-(γ-1,2,3-triazol

Computational drug discovery

Flexibility of the Flap in the Active Site of BACE1 as Revealed by Crystal Structures and MD Simulat

M. Ammonium transport proteins with changes in one of the conserved pore histidines have different p

Rapid and selective access to three distinct sets of indole-based heterocycles from a single set of

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dyna

Computational Screening for Active Compounds Targeting Protein

Highly diastereoselective synthesis of 3-indolylglycines

Structure and Synthesis of a Unique Isonitrile Lipid Isolated from the Marine Mollusk Actinocyclus p

Cyanobacterial Peptides as a Prototype for the Design of Potent β-Secretase Inhibitors and the

Classification of 5-HT(1A) receptor agonists and antagonists using GA-SVM method

Fragment-based prediction of skin sensitization using recursive partitioning

Identification of Pentacyclic Triterpenes Derivatives as Potent Inhibitors against Glycogen Phosphor

The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands.

Rhodium-Catalyzed Highly Enantioselective Addition of Arylboronic Acids to Cyclic Aldimines: Practic

Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity

Aquantum mechanics/molecular mechanics study on the hydrolysis mechamism of New Delhi metallo-B-lact

Highly Enantioselective of 2-Oxindoles-3-carboxylate Ester to Nitroole?ns Promoted by Cinchona Alkal

Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors

Discovery of Novel Dual-action Antidiabetic Agents that Inhibit Glycogen Phosphorylase and Activate

Asymmetric total synthesis and identification of tetrahydroprotoberberine

Estimation of Carcinogenicity using Molecular Fragments Tree

Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A computational study

Design and Synthesis of Polymeric Chiral Bicyclo[3.3.0] Diene as Reusable Ligand for Rhodium-Catalyzed Asymmetric 1,4-Addition

烷基杂环芳基二硫醚类化合物的合成及抗癌活性研究

Bioactive natural products from Chinese marine flora and fauna