中文摘要：

以683名男青少年为被试（初次测评时M=13.35岁;SD=0.51）,综合运用传统回归分析和新兴显著性区域检验,考察了MAOA基因rs6323多态性与同伴关系对青少年早期抑郁的交互作用及其表现形式。结果表明：当同伴接纳水平较低时,G等位基因携带者的抑郁水平表现出高于T等位基因携带者的趋势,当同伴接纳水平较高时,G型基因携带者的抑郁水平显著低于T等位基因携带者;同伴接纳可以显著预测G等位基因携带者的抑郁,但对T等位基因携带者的抑郁无显著预测作用;rs6323多态性与同伴拒绝的交互作用亦不显著。研究结果提示,同伴关系对MAOA基因与男青少年早期抑郁的关联起调节作用,且其作用形式部分支持不同易感性模型观点。

英文摘要：

Prior evidence suggested that MAOA gene was an potentially important candidate gene of depression, and its association with depression was mediated by environmental factors. However, most of the studies in this area have been guided by the ＂diathesis and stress model＂ and have typically focused on the interaction between MAOA gene and adverse environments, such as child maltreatment and stressful life events. Peer relationship, including peer accept and peer rejection, is among the important interpersonal relationships during early adolescence and plays a critical role in adolescent psychosocial development. However, it still remains unclear whether and how peer relationships interact with MAOA gene on adolescent depression. Additionally, previous studies examined mainly the effects of MAOA-u VNTR polymorphism on depression, and rarely focused on rs6323 polymorphism, which has been identified as a common polymorphism site among Asians. This study aimed to examine the interaction between rs6323 polymorphism and peer acceptance/rejection on early adolescent depression, with the differential susceptibility model as the theoretical frame. The participants in this study included 683 male adolescents originally drawn from a 3-year longitudinal study（n=1323） which investigated 11 junior high schools obtained through a random cluster sampling method. During the initial assessment（in 2010）, adolescents（grade 7） were on average 13.53 years old（SD=0.51）. Adolescents＇ depression were measured using self-rated Children＇s Depression Inventory（2010：a = 0.87; 2012： a = 0.88）, while peer relationship（including peer acceptance and peer rejection） were rated by peer nomination. DNA was extracted from saliva. Genotype at rs6323 was performed in real time with Mass ARRAY RT software version 3.0.0.4 and analyzed using the Mass ARRAY Typer software version 3.4（Sequenom）. A series of linear regression analyses were conducted using SPSS 19.0, followed by the ＂region of significance＂ analysis to