中文摘要：

以＂不同易感性模型＂为理论基础,1323名青少年为被试（初次测评时M=11.31岁;SD=0.49）,考察了5-HTR1A基因rs6295多态性与父母教养行为对青少年早期抑郁的交互作用及其性别差异。结果表明：当父母积极教养行为水平较高时,携带CC基因型的女青少年抑郁水平显著低于G等位基因携带者,当父母积极教养行为水平较低时,携带不同基因型的女青少年的抑郁水平无显著差异,但rs6295多态性与父母教养行为对男青少年的抑郁无显著交互作用。此外,rs6295多态性对男女青少年早期抑郁均无显著主效应。研究结果提示,rs6295多态性与父母教养行为对青少年早期抑郁的交互作用部分支持不同易感性模型观点,且存在性别差异,主要表现于女青少年群体中。本研究发现能够为基因-环境交互作用设计研究提供一定启示,同时亦能推进有关抑郁发生机制的研究。

英文摘要：

The extant findings showed 5-HTR1 A gene rs6295 polymorphism was associated with depression. However, most of them were mainly guided by the ＂diathesis and stress model＂ and typically focused on the interaction between risk alleles and adverse environments. According to the ＂differential susceptibility model＂, the individuals exclusively affected by negative contexts can also respond more favorably to positive environments, but the positive environments interacting with the same genes have scarcely been investigated. It also remains unclear whether there is a moderating effect of gender on the way rs6295 polymorphism interacting with environments. This study aimed to test the hypothesis of differential susceptibility model by examining the interaction of rs6295 polymorphism with positive and negative parenting behavior on early adolescent depression, and explore the mediating effect of adolescents＇ gender. Participants（n = 1323） were a subset of a 4-year longitudinal study（n = 2715） which investigated 14 primary schools in Jinan by random cluster sampling method. During the initial assessment（in 2008）, adolescents（grade 5） were on average 11.31 years old（SD = 0.49）, and mothers ranged in age from 35 to 40 years（M = 38.03, SD = 2.39）. Adolescents＇ depression were identified via self-rating on the Children＇s Depression Inventory（2008： ？ = 0.88; 2011： ？ = 0.89）, and parenting behavior were rated by mother-report questionnaire（positive： ？ = 0.85; negative： ？ = 0.72）. DNA was extracted from saliva. Genotype at rs6295 was performed in real time with Mass ARRAY RT software version 3.0.0.4 and analyzed using the Mass ARRAY Typer software version 3.4（Sequenom）. A series of linear regression analyses were conducted by SPSS 18.0. The results showed rs6295 polymorphism significantly interacted with positive parenting behaviors in predicting early adolescents＇ depression, and furthermore this interaction was moderated by adolescents＇ gender. Specifically, a