中文摘要：

目的 初步探讨抗原处理相关转运蛋白1（TAPl）基因rsl057141、rsll35216位点多态性与新疆汉族变应性鼻炎（AR）易感性的关系。方法：随机选择新疆医科大学第一附属医院耳鼻咽喉科门诊就诊的无血缘关系的汉族AR患者150例（AR组）和门诊体检健康对照150例（对照组），采用SNaPshotSNP分型技术检测300个样本rsl057141、rsll35216基因位点多态性，并与NCBI基因库中世界其他种族人群进行比较。结果：TAPl＊rsl057141基因型G／G、G／A、A／A在AR组中的频率分别为2．70％、33．30％、64．00％，在对照组中的频率分别为4．OO％、30．00％、66．OO％，2组问基因型频率分布差异无统计学意义（P〉O．05）。TAPl＊rsll35216基因型G／G、G／A、A／A在AR组中的频率分别为1．30％、27．30％、71．400A，在对照组中的频率分别为2．0％、28．7％、69．3％，2组间基因型频率分布差异无统计学意义（P）0．05）。新疆汉族TAPl＊rsl057141、rsll35216基因型及等位基因与世界其他人群相比较，差异均有统计学意义（P〈O．05）。结论：TAPl＊rsl057141、rsll35216多态性与新疆汉族AR易感性无关。新疆地区汉族人群中TAPl＊rsl057141、rsll35216位点基因型频率分布与世界其他种族人群均有差异。

英文摘要：

Objective：To investigate the association between transporter associated with antigen processing 1 （TAP1） rs1057141 and rs1135216 gene polymorphisms and predisposition to allergic rhinitis（AR） in Xinjiang Han people. Method：A case control study was conducted. The region of the TAP1 ＊ rs1057141 and rs1135216 was studied in 150 Xinjiang Han people with allergic rhinitis and 150 normal controls by using SNaPshot system, and these data were compared with other ethics groups in the world according to the NCBI gene bank. Result：The gen- otypes distribution of the group were in the Hardy-Weinberg equilibrium（P〉0.05）. The frequencies of three gen- otypes（G/G,G/A,A/A） of TAP1 ＊ rs1057141 were 4. 00%, 30. 00%, 66. 00% in controls and 2. 70%, 33. 300/00, 64.00% in AR groups , which showed no difference（P〉0.05）. The frequencies of three genotypes（G/ G,G/A,A/A） of TAP1 ＊ rs1135216 were 2.0% ,28.7% ,69.3% in controls and 1.30%,27.30% ,71.40% in AR groups, which showed no difference either（P〉0.05）. According to the NCBI database, there was difference be tween Xinjiang Han people and other ethnics in the world. Conclusion：Lacking association was found between the mutation of TAP1 ~ rs1057141,rsl135216 gene G allele and allergic rhinitis in the Xinjiang Han people. Maybe TAP1 ＊ rs1057141 ,rs1135216 were not susceptibility genes to AR. And apparent differences existed in TAP1 gene polymorphisms between Xinjiang Han people and other ethnic groups in the world.