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中文摘要：
逍遥散有明确的抗抑郁作用，但其作用机制尚不清楚。从神经递质、神经营养素、下丘脑-垂体-肾上腺轴、氨基酸、脂质和能量代谢以及炎症因子等方面对逍遥散抗抑郁机制进行分析，归纳总结了逍遥散抗抑郁的代谢网络调控机制。结果显示逍遥散作用于多个靶点，通过调节体内代谢平衡发挥抗抑郁作用。
英文摘要：
The anti-depressive effect of Xiaoyaosan is obvious; However, the potential mechanism remains unclear. This paper elucidated the antidepressive mechanism of Xiaoyaosan from the fields of neurotransmitter, neurotrophins, hypothalamic-pituitary- adrenal axis, metabolisms of amino acid, lipid, and energy, inflammatory factor, and metabolic network figure. The comprehensive results implicate that Xiaoyaosan plays as antidepressant via the role of action on multiple targets and regulation in the metabolic balance in vivo.
同期刊论文项目
同项目期刊论文
1H-NMR-Based Metabonomic Studies on the Anti-Depressant Effect of Genipin in the ChronicUnpredictabl
H-1 NMR-based metabolic profiling of liver in chronic unpredictable mild stress rats with genipin tr
Investigation on the antidepressant effect of sea buckthorn seed oil through the GC-MS-based metabol
1 H-NMR-Based Metabonomic Studies on the Anti-Depressant Effect of Genipin in the Chronic Unpredicta
Plasma-metabolite-biomarkers for the therapeutic response in depressed patients by the traditional C
Dynamic analysis of the endogenous metabolites in depressed patients treated with TCM formula Xiaoya
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