中文摘要：

目的研究颈动脉硬化患者不同中医证型与血清炎症因子水平的关系。方法选择颈动脉硬化患者176例，其中痰浊内阻证72例，血瘀证64例，精髓亏虚证40例；另选择同期门诊健康体检者作为健康对照组。晨取空腹肘静脉血，采用酶联免疫吸附法（ELISA）测定血清内皮细胞黏附分子-1（ICAM-1）、血管细胞黏附分子-1（VCAM-1）、E-选择素、白细胞介素-6（IL-6）和C-反应蛋白（CRP）等炎症因子水平；比较各证型颈动脉硬化患者血清黏附分子水平。结果不同证型颈动脉硬化患者血清ICAM-1、VCAM-1、E-选择紊、IL-6和CRP均较健康对照组显著上升（P〈0．05或P〈0．01），其中痰浊内阻证组患者血清ICAM-1、VCAM-1均较血瘀证组和精髓亏虚证组患者显著上升[ICAM-1分别为（382．71±85．78）、（358．76±84．06）、（356．27±91．59）μg／L；VCAM-1分别为（588．29±104．06）、（542．74±90．27）、（523．23±86．07）μg／L，P〈0．05或P〈0．01]。结论颈动脉硬化痰浊内阻证患者外周血中炎症因子水平的变化具有一定特异性，痰的微观实质可能与黏附分子之间存在某种内在联系。

英文摘要：

Objective To study the relationship of levels of several serum inflammatory factors with different traditional Chinese medicine （TCM） syndromes of patients with carotid artery atherosclerosis. Methods The blood samples were collected in the morning from the ulnar vein in 176 patients with carotid artery atherosclerosis, including 72 cases with phlegm syndrome, 64, blood stasis syndrome, and 40, marrow deficiency syndrome, and at the same time, healthy persons were chosen as controls. The concentrations of serum intercellular adhesion molecule-1 （ICAM-1）, vascular cell adhesion molecule-1 （VCAM-1）, E-selectin, interleukin-6 （IL-6） and C-reactive protein （CRP） in blood were tested by means of enzyme linked immunosorbent assay （ELISA）. In the meantime, according to the TCM syndrome, the subjects were divided into three groups. The changes of concentrations of inflammatory factors were compared in different groups. Results Compared with the control group, the levels of inflammatory factors in the patients with carotid artery atherosclerosis were higher （P〈0.05 or P〈0.01）, and the levels of ICAM-1 and VCAM-1 in phlegm group were higher than those in the blood stasis group and marrow deficiency group [ICAM-1： （382.71± 85.78）, （358.76±84.06） and （356.27±91.59） μg/L; VCAM-1： （588.29±104.06）, （542.74±90.27） and （523.23±86.07） μg/L, P〈0.05 or P〈0. 01]. Conclusion The level change of serum cellular adhesion molecules in peripheral blood of patients with carotid artery atherosclerosis possesses certain distinctive character, and the microcosmic essence of phlegm probably has certain internal association with adhesion molecules.