目的应用路径分析的方法对颈动脉粥样硬化中医证候转化进行定量分析。方法收集397例颈动脉粥样硬化患者临床资料,对患者中医证候进行路径分析。结果①精髓亏虚证的发生受到痰浊内阻证和血瘀证的显著影响;②气虚证的发生受到精髓亏虚证、痰浊内阻证和血瘀证的显著影响;③痰浊内阻证的发生受到气虚证、血瘀证和气滞证的显著影响;④血瘀证的发生受到气虚证、痰浊内阻证和气滞证的显著影响;⑤气滞证的发生受到痰浊内阻证和血瘀证的显著影响。结论在颈动脉粥样硬化的发病过程中,包含了"虚"与"损"两方面的因素,而这两者之间又可以相互影响与转化,形成不同证候之间的转化。路径分析能够定量描述颈动脉粥样硬化的中医证候转换关系。
Objective To analyze the traditional Chinese medicine (TCM) syndromes of carotid arteriosclerosis (CA),by the way of path analysis.Methods 237 CA patients were researched,and their symptoms,tongues and pulses were recorded.Then path analysis way was used to analyze these patients’ TCM syndromes.Results Marrow deficiency was induced by phlegm stasis and blood stasis;qi deficiency was induced by marrow deficiency,phlegm stasis and blood stasis;phlegm stasis was induced by qi deficiency,blood stasis and qi stasis;blood stasis was induced by qi deficiency,phlegm stasis and qi stasis;qi stasis was induced by phlegm stasis and blood stasis.Conclusions In CA TCM syndromes,deficiency and hurt are two important factors.These two factors could influence each other,and show different syndromes.And the way of path analysis could help analyze the CA patients’ TCM syndromes.