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中文摘要：
KAP-1（又称TIF1β，TRIM28等）是一种转录中介因子，在诸多转录调控复合体中起桥梁作用。它通过其N端RBCC结构域与含KRAB结构域的锌指蛋白、MDM2、MM1、C／EBPβ等相互作用；通过C端的PHD及BrD结构域与SETDB1、Mi-2α等分子相互作用，参与形成具有组蛋白甲基化酶或组蛋白去乙酰化酶活性的复合体；通过中间的HP1BD区域与HP1蛋白相互作用，进而与组蛋白相结合。大量研究表明，KAP-1作为一个桥梁分子，主要以共抑制因子形式参与转录抑制复合体的形成，在某些复合体中也可作为共激活因子发挥作用。KAP-1参与形成的复合体在精细胞发育、胚胎早期发育等生理过程中发挥重要的调控作用，这种调控属于表观遗传调控范畴。
英文摘要：
KAP-1 （Alternative names： TIFIβ or TRIM28） is one member of transcriptional intermediary factors, which acts as a scaffold in many transcription regulation complexes. The N-terminal RBCC domain of KAP-1 can interact with KRAB-ZFPs, MDM2, MM1, C/EBPβ, etc. KAP-1＇s C-terminal PHD and Bromodomain is two integrated transcriptional repression domains, which interact with SETDB 1, Mi-2α and other proteins to form complexes with histone deacetylase or methyltransferase activity. In addition, KAP-1 can interact with HPls （heterochromatin protein 1） and then bind to histones via its HP1BD which is a small segment in the central region of KAP-1. It is indicated by many researches that KAP-1, a scaffold protein in transcription regulation, mainly acts as a corepressor in many repression complexes. Meanwhile, it also acts as a coactivator sometimes. It is reported that KAP-1 related transcription regulation complexes exert functions essential for spermiogenesis and early embryo development. This regulation is one pattern of epigenetic regulations.
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