中文摘要：

含氟肉桂醛与4-氨基-5-（3,4,5-三甲氧基苯基）-1,2,4-三唑-3-硫酮（2）缩合生成5-（3,4,5-三甲氧基苯基）-4-取代苯基烯丙亚胺基-1,2,4-三唑-3-硫酮（3）, 再烷基化为新型含氟肉桂醛1,2,4-三唑亚胺（4）. 化合物结构经1H NMR, 13C NMR, IR以及元素分析确认, 并用X-ray单晶衍射测定了化合物4g的晶体结构, 证实了分子中两个环外双键N＝C和C＝C均为E-式构型. 初步生物活性测试结果表明, 部分化合物具有抗植物病毒活性.

英文摘要：

A series of 4-（substituted-3-phenylallyideneamino）-3-（3,4,5-trimethoxyphenyl）-1H-1,2,4-triazole-5（4H）-thione （3） were synthesized by condensation reaction of 4-amino-3-（3,4,5-trimethoxyphenyl）- 1H-1,2,4-triazole-5（4H）-thione （2） with various fluorocinnamaldehydes. Alkylation of 3 with alkyl halides afforded N-1,2,4-triazole moieties imines containing fluorocinnamylidene 4. Their structures were confirmed by 1H NMR, 13C NMR, IR and elemental analyses. The single crystal structure of compound 4g was deter- mined by X-ray diffraction analysis, which revealed that the two double bonds N=C and C=C outside the rings were of E,E-configurations. The preliminary bioassay showed that some of them exhibited moderate antiviral activity.