中文摘要：

MicroRNAs (miRNAs ) 作为小调整 RNA 的一个班正在出现，并且 miRNAs 的改变在人的癌症的开始和前进被含有。我们的学习在房间线能压制的 OVCAR3 卵巢的癌症显示出 miR-20a 的那抑制，而 miR-20a 的 overexpression 能提高房间长期的增长和侵略。我们也作为 miR-20a 的直接目标基因证实了淀粉的先锋蛋白质(应用软件) 。而且，应用软件表示的抑制能也支持卵巢的癌症房间增长和侵略，它与 miR-20a overexpression 的结果一致。因此，我们断定应用软件的规定是重要机制让 miR-20a 在卵巢的癌症房间支持增长和侵略。

英文摘要：

MicroRNAs （miRNAs） are emerging as a class of small regulated RNAs, and the alterations of miRNAs are implicated in the initiation and progression of human cancers. Our study shows that inhibition of miR-20a in OVCAR3 ovarian cancer cell line could suppress, whereas overex- pression of miR-20a could enhance cell long-term proliferation and invasion. We also confirmed amyloid precursor protein （APP） as a direct target gene of miR-20a. Furthermore, suppression of APP expression could also promote ovarian cancer cell proliferation and invasion, which is consistent with the results of miR-20a overexpression. Therefore, we concluded that the regulation of APP is an important mechanism for miR-20a to promote proliferation and invasion in ovarian cancer cells.