中文摘要：

试图在紫外放射 B (UVB ) 上评估 baicalin 的效果的这研究调停了在老鼠皮肤的 microRNA (miRNA ) 表示。我们决定 miRNA 表示在 UVB 介绍照耀的鼠标， baicalin 对待照耀的鼠标，和未经治疗的鼠标，并且进行了 TargetScan 和基因本体论分析预言 miRNA 目标。三 miRNAs (mmu-miR-125a-5p， mmu-miR-146a，和 mmu-miR-141 ) 是 downregulated 和另外一个(mmu-miR-188-5p， mmu-miR-223 和 mmu-miR-22 ) 三是在 UVB 的 upregulated 照耀的老鼠与未经治疗的老鼠相比。另外，这些 miRNAs 被预言与 photocarcinogenesis， hypomethylation 和 apoptosis 有关。三 miRNAs (mmu-miR-378， mmu-miR-199a-3p 和 mmu-miR-181b ) 是 downregulated，(mmu-miR-23a ) 是在 baicalin 的 upregulated 对待的老鼠与 UVB 相比，照耀的老鼠，和他们被预言修理发信号与 DNA 有关小径。这些 deregulated miRNAs 潜在地涉及 photodamage 的致病，并且可以帮助导致 UVB 的 dermatoses 的处理和预防。

英文摘要：

This study aimed to evaluate the effects of baicalin on ultraviolet radiation B （UVB）-mediated microRNA （miRNA） expression in mouse skin. We determined miRNA expression profiles in UVB irradiated mice, baicalin treated irradiated mice, and untreated mice, and conducted TargetScan and Gene Ontology analyses to predict miRNA targets. Three miRNAs （mmu-miR-125a-5p, mmu-miR-146a, and mmu-miR-141） were downregulated and another three （mmu-miR-188-5p, mmu-miR-223 and mmu-miR-22） were upregulated in UVB irradiated mice compared with untreated mice. Additionally, these miRNAs were predicted to be related to photocarcinogenesis, hypomethylation and apoptosis. Three miRNAs （mmu-miR-378, mmu-miR-199a-3p and mmu-miR-181b） were downregulated and one （mmu-miR-23a） was upregulated in baicalin treated mice compared with UVB irradiated mice, and they were predicted to be related to DNA repair signaling pathway. These deregulated miRNAs are potentially involved in the pathogenesis of photodamage, and may aid treatment and prevention of UVB-induced dermatoses.