中文摘要：

目的：探讨四逆散对疲劳大鼠学习记忆及脑内GABA_B1受体的影响。方法：应用游泳训练和睡眠剥夺方法复制疲劳动物模型,运用Y-迷宫检测各组大鼠的学习记忆能力,采用免疫组化方法检测大鼠脑内GABA_B1受体阳性反应物的变化。结果：模型组与正常组相比,大鼠Y-迷宫正确反应率明显下降,错误反应率明显升高,大鼠脑内GABA_B1的阳性反应物数目明显增多;中药治疗组与模型组相比,正确反应率明显升高,错误反应次数明显下降,脑内GABA_B1受体的阳性反应物数目明显减少。结论：四逆散对疲劳大鼠学习记忆能力的下降具有改善作用。

英文摘要：

Objective： To investigate the effects of Sinisan on learning and memory in fatigue model and the expression of GABA B1 receptor in rats brain.Methods： The Fatigue models were taken by the method of swimming traning and sleep deprivation.Evaluate learning and memory changes through Y maze and the changes of positive cell counts of GABA B1 receptors in rat brain by immunohis-tochemical method.Results： The correct response rate of Y-maze correctly were obviously lower in the model group than those in the normal control group.The error rate of Y maze were obviously higher in the model group than those in the normal control group.The expression of GABA B1 receptors in rat brain were higher in the model group than those in the normal control group.Sinisan can signifi-cantly increase the correct rate of Y-maze correctly and decrease the error rate and decrease the expression of GABA B1 in rat brain.Conclusion： Sinisan can increase the abilities of learning and memory in fatigue rats.