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Wnt信号膜质转导的机制
  • ISSN号：1004-0374
  • 期刊名称：《生命科学》
  • 时间：0
  • 分类：Q257[生物学—细胞生物学]
  • 作者机构：[1]中国科学院上海生命科学研究院生物化学与细胞生物学研究所、分子生物学国家重点实验室,上海200031
  • 相关基金：国家杰出青年科学基金项目（39525005,39928008）：国家自然科学基金重大项目（39990600）;国家自然科学基金重点项目（30930052,31230044）：国家自然科学基金创新研究群体项目（30821065）;国家自然科学基金重大研究计划项目（90813024）;国家自然科学基金面上项目（30600305,30900763,31100532）
作者： 贾莹莹[1], 李林[1]
关键词： WNT信号, 分子机制, 信号膜质传递, Wnt signal pathway, molecular mechanism, signal transferring from membrane to cytoplasm
中文摘要：

Wnt信号通路是一条高度保守的信号转导通路，在生物体多个发育过程以及一系列疾病发生中发挥重要作用。Wnt信号通路重要的生物学功能和复杂的信号转导调控网络引起了人们广泛和持续的研究兴趣。介绍了经典Wnt信号通路信号转导的分子框架，结合自身实验室新的研究发现，重点阐述Wnt信号由细胞膜上向细胞质内转导的机制。

英文摘要：

Wnt signaling pathway is a highly conserved signal transduction pathway, and plays important roles in multiple biological developmental processes and diseases. The biological function and complicated signal transduction network have aroused the widespread study interest. This review introduces the molecular framework of classical Wnt signaling pathway, combined with the findings from our own laboratory, focuses on the mechanism of Wnt signaling transferring from cell membrane to cytoplasm.

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期刊信息
  • 《生命科学》
  • 北大核心期刊（2008版）
  • 主管单位:中国科学院
  • 主办单位:国家自然科学基金委员会生命科学部 中国科学院生命科学与生物技术局 中国科学院生命科学和医学学部 中国科学院上海生命科学研究院
  • 主编：王恩多
  • 地址：上海岳阳路319号31号楼B座403中国科学院上海文献情报中心
  • 邮编：200031
  • 邮箱：CBLS@SIBS.AC.CN
  • 电话：021-54922830
  • 国际标准刊号：ISSN：1004-0374
  • 国内统一刊号：ISSN：31-1600/Q
  • 邮发代号:4-628
  • 获奖情况:
  • 1996年获上海市优秀科技期刊评比一等奖
  • 国内外数据库收录:
  • 中国中国科技核心期刊,中国北大核心期刊（2008版）
  • 被引量:9112