中文摘要：

碳存储调控因子A（carbon storage regulator,CsrA）是一种RNA结合蛋白,在细菌的碳代谢、生物被膜形成、运动性、病原菌毒力、群体感应、环二鸟苷酸信号合成、应激感应等多种生理过程中具有重要调节功能,是全局性调控蛋白.它通过与靶标mRNA的特异结合,抑制其翻译或增强其稳定性来调控下游基因的表达,属于转录后调控因子的范畴.CsrA蛋白的表达与活性受碳存储调控（Csr）系统本身多个自主调节回路的精密控制：一些小的非编码RNA（snmRNAs,如CsrB/C）作为拮抗因子与CsrA二聚体结合并抑制其活性;而这些snmRNAs在体内又可在CsrD的辅助下被核糖核酸内切酶E和多核苷酸磷酸化酶降解,释放CsrA的活性.当前,对于Csr系统的调节作用、调控通路与机制的研究是细菌学研究的热点,本文综述了该蛋白及Csr系统的结构、功能和作用机制的最新研究进展.

英文摘要：

Carbon storage regulator （CsrA） is a small RNA binding protein to coordinate the expressionof a diverse set of genes in bacteria at the post-transcription level. CsrA dimers can positively or negatively regulate the translation process and/or the stability of target transcripts of the primary and secondary metabolic pathways, biofilm formation, motility, virulence circuitry of pathogens, quorum sensing, cyclic-di-GMP synthesis, and stress response systems. The CsrA expression and activity is governed by an extensive autoregulatory circuitry in Escherichia coli, called the Csr system, in which small non-messenger RNAs（ snmRNAs, like CsrB/C） bind and sequester CsrA dimers. The function of CsrB and CsrC snmRNAs in E. coli requires CsrD, a GGDEF-EAL domain superfamily protein, to facilitate nucleases RNase E and PNPase. This review summarizes the latest research regarding the structure and function of the proteins in Csr sustems