中文摘要：

通过活性追踪分离从千斤拔（Flemingia philippinensis Merr.et Rolfe.）干燥根中分离到9个化合物,通过现代波谱学方法鉴定化学结构分别为Eriosematin（1）;Flemichapparin C （2）;咖啡酸三十烷酯（3）;Flemiphilippinin A（4）;大黄素甲醚（5）;染料木黄酮（6）;Osajin（7）;3,5-二羟基肉桂酸二十八酯（8）;Lupinalbin A （9）,化合物3和8为千斤拔属中首次分离鉴定.体外抗肿瘤活性研究结果表明,黄酮类化合物1、4、6、7和9对MCF-7、Hela、HepG2、B16细胞均具有较强的增殖抑制活性,可能是千斤拔的主要抗肿瘤活性成分.

英文摘要：

Bioassay-directed fractionation of the Flemingia philippinensis Merr.et Rolfe led to isolation of compounds by modem chromatography.Nine compounds were isolated and identified as Eriosematin（1）,Flemichapparin C （2）,3＇,4＇-Dihydroxy-trans-cinamic acid myricyl ester（3）,Flemiphilippinin A（4）,Physcion（10）,Genistein（6）,Osajin（7）,octacosyl-3,5-dihydroxy-cinnamate （8）,Lupinalbin A （9）.Compounds 3 and 8 were isolated and identificated from the Flemingia genus for the first time.And their anti-tumor activities were evaluated.Results demonstrated that flavonoids compounds 1,4,6,7 and 9 exhibit significant anti-proliferative activity towards some well established cancer cell lines,e.g.MCF-7,Hela,HepG2 and B16,which showed these flavonoids compounds may be the main anti-cancer compounds of Flemingia philippinensis Merr.et Rolfe.