中文摘要：

目的评价酶联免疫吸附（ELISA）法检测血清胃泌素释放前体肽（Pro-GRP）诊断小细胞肺癌（SCLC）的价值。方法检索PubMed、Cochrane、ISI Web of Knowledge等数据库,检索时间为1990～2009年发表的文献,收集关于ELISA法检测血清Pro-GRP诊断SCLC的相关文献并进行信息统计、科学性评估及质量分级;采用Meta-Disc1.4软件进行数据分析;通过汇总敏感度、特异度、汇总似然比及汇总受试者工作特征曲线（SROC曲线）等统计指标综合评价ELISA法检测血清Pro-GRP对SCLC的早期诊断价值。结果共纳入11篇文献,其中英文文献6篇,中文文献5篇,样本量为3 554例,其中经病理学确诊的SCLC为1 122例,NSCLC为2 432例。异质性检验显示纳入研究齐性好,通过确定模型的汇总计算得出汇总敏感度为0.75（0.73,0.78）,汇总特异度为0.93（0.92,0.94）,汇总阳性似然比11.44,汇总阴性似然比0.27,SROC曲线下面积为0.93。结论 Pro-GRP在早期诊断SCLC中具有一定的参考价值,可作为较重要的参考指标之一。

英文摘要：

Objective To evaluate the diagnostic value of serum pro-gastrin-releasing peptide（Pro-GRP） in patients with small cell lung cancer（SCLC） through ELISA method.Methods We searched PubMed,Cochrane,ISI Web of Knowledge and other databases（1990-2009） to collect studies which evaluated the diagnostic value of Pro-GRP in patients with SCLC.The statistical information and quality of science were assessed and classified.The data were analyzed using Meta-Disc1.4 software.The diagnostic value of Pro-GRP in SCLC was evaluated by the pooled sensitivity,specificity,likelihood ratio（LR） and summary receiver operating characteristic curve（SROC curve） statistical indicators.Results Eleven pieces literature were collected including 6 in English and 5 in Chinese,and 3 554 cases were included in the study（1 122 SCLC and 2 432 non-SCLC patients,all diagnosed pathologically）.Heterogeneity test showed that the homogeneity of the study was good.By using deterministic models to analyze the data,the value of the weighted sensitivity was 0.75,the specificity was 0.93,the positive likelihood ratio was 11.44,negative likelihood ratio was 0.27,and the SROC area under the curve（AUC） was 0.93.Conclusion Pro-GRP can be regarded as one of the valuable reference tests in patients with SCLC.