中文摘要：

将微晶纤维素（MCC）溶于1-烯丙基-3-甲基氯代咪唑（AmimCl）离子液体中，使用4-二甲氨基毗啶（DMAP）作为催化剂，采用开环聚合的方法，成功合成了纤维素接枝L-聚乳酸（Cellulose-g—PLLA），并采用乳化-溶剂挥发法成功制备了纤维素微球。通过核磁共振（HNMR）、透射电子显微镜（TEM）等对聚合物进行表征。对微球的降解性、缓释性及缓释动力学进行了探讨。结果表明，Cellulose-g-PLLA微球具有作为缓释药物载体的能力。

英文摘要：

A cellulose-based degradable material cellulosegraft-poly（L-lactide） was successfully attained via ring-opening polymerization （ROP） in an ionic liquid. The microsphere was prepared by emulsification-solvent evaporation method. The structure and morphology of the polymer were characterized by nuclear magnetic resonance （NMB） and transmission electron microscope （TEM）. The degradation of cellulose-g- PLLA demonstrate significantly different characteristics, which dominated the drug-release mechanism of the cellulose-g- PLLA microspheres. It showed that the drug-release rate increased with the decrease of graft degree of the cellulose-g- PLLA. Consequently, the cellulose-g-PLLA microspheres might be used as a potential polymer for the controlled release of drugs.