中文摘要：

空 mesoporous nanomaterial 由于他们的唯一的空结构是一种有希望的新药交货系统。以便评估硅石 nanorattle (SN ) 的毒性在 vivo 的粒子， 40 只雌老鼠在这研究被使用调查尖锐毒性和氧化损坏。老鼠静脉内地与 SN 暂停被注射在无菌在 40， 80 和 240 mg/kg 的 5% 葡萄糖分别地。控制组被管理与相等卷 5% 葡萄糖。重量，喂吸入，血液学分析，血生物化学的试金和组织病理学说诊断被检验。草皮， GSH 和猫的活动也被测量。结果证明在与 240 mg/kg SN 对待的老鼠的中高音和著名计算机生产厂商的层次作为与控制组相比显著地增加了(P < 0.05 ) ，而甜面包和 CREA 的内容 unremarkably 变化了。SN 在肝导致的草皮的活动显著地减少了(P < 0.05 ) 。在摘要，这研究表明肝是 SN 的目标机关。草皮的活动在 SN 引起的肝损害起了一个重要作用，这能也被结束。

英文摘要：

Hollow mesoporous nanomaterial is a kind of promising new drug delivery system due to their unique hollow structures.In order to evaluate the toxicity of silica nanorattle （SN） particles in vivo,40 female mice were used in this study to investigate the acute toxicity and oxidative damage.Mice were intravenously injected with SN suspension in sterile 5% glucose at 40,80 and 240 mg/kg,respectively.The control group was administrated with equal-volume 5% glucose.Weight,feed intake,hematology analysis,blood biochemical assay and histopathology diagnosis were examined.The activities of SOD,GSH and CAT were measured as well.The results demonstrated that the levels of ALT and AST in the mice treated with 240 mg/kg SN increased significantly as compared with the control group （P〈0.05）,whereas the contents of BUN and CREA changed unremarkably.The activity of SOD induced by SN in the liver decreased significantly （P〈0.05）.In summary,this study revealed that liver was the target organ of the SN.It also can be concluded that activity of SOD played an important role in liver injury caused by SN.