中文摘要：

硅石 nanorattle 与空并且 mesoporous 结构被证明了是一个优秀的药搬运人。然而，怎么从硅石 nanorattle 控制药版本仍然是挑战。在这研究，我们设计了二个方法，在原处，在水(W/O/W ) 里的油的聚合方法和水加倍乳剂方法， poly 覆盖 nanosized (lactic-co-glycolic 酸)(PLGA ) 层到为控制药版本行为的硅石 nanorattle 的表面上。恐水病的 antitumor 药 docetaxel 被装进 PLGA 涂的硅石 nanorattle (PLGA@SN ) 。人的肝癌症 HepG2 房间上的药版本侧面，细胞的举起和 cytotoxicity 被评估证明 PLGA 层在调节药交货起一个有效作用。

英文摘要：

Silica nanorattle with hollow and mesoporous structure has been proven to be an excellent drug carder. However, how to control the drug release from silica nanorattle is still a challenge. In this study, we designed two methods, in-situ polymerization method and water in oil in water （W/O/W） double emulsion method, to coat a nanosized poly（lactic-co-glycolic acid） （PLGA） layer onto the surface of silica nanorattle for controlling the drug release behavior. Hydrophobic antitumor drug docetaxel was loaded into the PLGA coated silica nanorattle （PLGA@SN）. The drug release profile, cellular uptake and cytotoxicity on human liver cancer HepG2 cells were evaluated to prove that the PLGA layer plays an effective role in tuning the drug delivery.