中文摘要：

钙调神经磷酸酶(calcineurin,CN)作为机体中的一种丝/苏氨酸磷酸酶,在关键的生物学过程中发挥着重要作用.RCANs(regulators of calcineurin)是CN的一类内源调节因子,其家族成员在细胞中能够通过与CN在结构上的相互结合,起到调节CN活性的作用.而近来研究发现,该调节因子还可参与到CN-NFAT信号通路中发挥功能,从而与CN依赖的生理和病理过程的调控密切相关.因此,有必要对RCAN基因、RCANs蛋白与CN的相互作用以及该家族成员在病理条件下的重要功能作一个较为全面的综述,这些基础研究工作的进展将有助于为寻找新的疾病治疗方法和药物开辟新的途径.

英文摘要：

Calcineurin is a serine-threonine protein phosphatase that plays a pivotal role in a wide series of crucial physiologic processes such as T-cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. A new family of regulators of calcineurin (RCANs) has been shown to modulate calcineurin activity through direct binding of it in vivo. Calcineurindependent signals are transduced to the nucleus by nuclear factor of activated T-cells (NFAT) transcription factors that undergo nuclear t...