中文摘要：

胃饥饿素（ghrelin）基因可以被翻译和修饰成为三种主要的基因产物,即ghrelin肽、非乙酰化的ghrelin以及肥胖抑制素（obestatin）。这些ghrelin基因的产物在免疫系统、神经内分泌功能、物质代谢、肿瘤发生和炎症反应中通过调控细胞凋亡、促进细胞增生或影响细胞因子释放等过程发挥重要的调节作用。本文主要针对既往研究中较少涉及的ghrelin基因及其产物和相应受体在急性和慢性炎症反应中的作用方式和相关信号通路进行了综述,并对其参与败血症、类风湿性关节炎、炎性肠病等炎性疾病的发生及在疾病治疗中的应用进行了总结。

英文摘要：

Ghrelin gene can be translated and modified into three main products, the peptides ghrelin, unacylated ghrelin and obestatin. They have been reported to have several actions on the immune system, neuroendocrinological function, metabolism, tumorigenesis and inflammation through the process of regulating the cell apoptosis, proliferation or cytokine release. This review principally aimed to summarize the previous studies regarding the less known role of ghrelin gene and its products as well as their receptors in the acting ways and related signaling pathways of acute and chronic inflammation, in addition, to outline both its engagement of the onset of inflammatory diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease and their applications in the treatment of diseases.