中文摘要：

滋养细胞迁移与细胞骨架密切相关,若细胞骨架中微丝微管的动态性重组受阻,则滋养细胞迁移受到抑制,其侵袭入子宫螺旋动脉及蜕膜层不足,导致滋养细胞着床变浅,进而引起胎盘缺血缺氧,最终导致子痫前期的发生。而滋养细胞浅着床是子痫前期发病的关键环节,滋养细胞的浸润深度直接影响子痫前期的发病。因此研究细胞骨架与人滋养细胞迁移之间的关系对深入了解子痫前期的发病机制具有重要意义。近年来关于细胞骨架在滋养细胞迁移中的作用时有报道,本文对此加以综合分析。

英文摘要：

The migration and invasion of trophoblast are closely associated w ith the c y toskeleton. The blocking of cytoskeleton＇s dynamic restructuring might inhibit the migration of the cell into the spiral artery and decidua, and it would lead to a shallow trophoblast implantation, ischemia and anoxia of placentome, and the occurrence of preeclampsia（PE） eventually. Shallow trophoblast implantation plays a key role in the development of PE, and the depth of implantation was shown to be directly related to the occurrence of PE. So the research in regard to the relationship between cytoskeleton and trophoblast＇s migration are of great significance for the understanding of the pathogenesis of PE. In recent years a number of studies on the role of cytoskeleton in shallow implantation have been reported from time to time, and their results will be analyzed comprehensively in the present article.