中文摘要：

机体通过模式识别受体识别病原相关分子模式,并激活天然免疫应答和获得性免疫应答,然而,沙门菌已进化出相应的逃逸机制逃避宿主的防御。沙门菌的一种免疫逃逸机制是干扰Toll样受体-核转录因子κB（TLRs-NF-κB）信号通路,包括修饰识别病原相关分子模式（PAMPs）、分泌TIR模拟物和抑制IκB的降解等;另一种机制是树突状细胞（DCs）介导的免疫逃逸,包括抑制DCs递呈抗原、降低FliC的表达和依附DCs扩散等。利用沙门菌的免疫逃逸策略,可为沙门菌新型疫苗和抑炎性药物分子设计提供新思路。

英文摘要：

Hosts recognize pathogen-associated molecular patterns（PAMPs）by pattern recognition receptors（PRRs）to activate the innate and adaptive immune response.However,Salmonellahas evolved corresponding evasion mechanisms to escape host immune defense.One of evasion mechanisms by Salmonellais to interfere with Toll like receptor-nuclear factorκB（TLRs-NF-κB）signaling,including modifying PAMPs,secreting TIR mimics and inhibiting the degradation of IκB.The other evasion mechanisms mediated by dendritic cells（DCs）include impairing antigen presentation by DCs,reducing FliC production,migrating attached to DCs and forming SCV.To exploit immune evasion mechanisms by Salmonella will provide new idea for the design of effective vaccines and drugs.