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Insights into the mechanism of CXCL12-mediated signaling in trophoblast functions and placental angiogenesis
  • ISSN号:1672-9145
  • 期刊名称:《生物化学与生物物理学报:英文版》
  • 时间:0
  • 分类:Q463[生物学—生理学] Q51[生物学—生物化学]
  • 作者机构:[1]Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China, [2]The First Student Brigade, The Fourth Military Medical University, Xi'an 710032, China, [3]Department of Clinical Immunology, PLA Specialized Research Institute of Rheumatism & Immunity, Xi-jing Hospital, The Fourth Military Medical University, Xi'an 710032, China, [4]Department of Respiratory Medicine, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, China, [5]Institute of Neurosciences, School of Basic Medical Sciences, The Fourth Military Medical University, Xi'an 710032, China, [6]Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China, [7]Department of Orthopedics, Hainan Branch of PLA General Hospital, Sanya 572013, China
  • 相关基金:This work was supported by the grants from the National Natural Science Foundation of China (Nos. 81471474, 31000660, and 81373200), the China Postdoctoral Science Foundation (Nos. 2014T70964 and 2013M532203), and Tangdu Hospital Reserve Per- sonnel Fund to X.Z.
中文摘要:

chemokine CXCL12 和它的受体 CXCR4 是重要的表明为人的胚囊培植和怀孕的前进要求的部件。成长证据显示 CXCL12/CXCR4 轴能调整 trophoblast 功能和改变的子宫的螺线动脉,它在胎座式和胎儿的结果起一个基本作用。孤儿受体 CXCR7 也被相信部分调整 CXCL12/CXCR4 轴的功能。另外, CXCL12/CXCR4/CXCR7 轴能提高在象子宫的自然漂亮房间那样的 trophoblasts 和蜕膜的房间和涉及 trophoblast 区别和侵略和胎盘的 angiogenesis 的规定的蜕膜的 stromal 房间之间的串音。另外,最近的研究证明那 CXCL12 表情与 preeclampsia 在胎盘和怀孕女人的中间三个月的羊膜的液体被提高,暗示 CXCL12 的 dysregulation 起在 preeclampsia 的致病的一个作用。在 trophoblast 功能和胎盘的 angiogenesis 的调停 CXCL12 的发信号的规章的机制的进一步的理解可以帮助为联系怀孕的疾病设计新奇治疗学的途径。

英文摘要:

The chemokine CXCL12 and its receptor CXCR4 are important signaling components required for human blastocyst implantation and the progression of pregnancy. Growing evidence indicates that the CXCL12/CXCR4 axis can regulate trophoblast function and uterine spiral artery remodeling, which plays a fundamental role in placentation and fetal outcome. The orphan receptor CXCR7 is also believed to partly regulate the function of the CXCL12/CXCR4 axis. Additionally, the CXCL12/ CXCR4/CXCR7 axis can enhance the cross-talk between trophoblasts and decidual cells such as uter- ine natural killer cells and decidual stromal cells which are involved in regulation of trophoblast dif- ferentiation and invasion and placental angiogenesis. In addition, recent studies proved that CXCL12 expression is elevated in the placenta and mid-trimester amniotic fluid of pregnant women with pre- eclampsia, implying that dysregulation of CXCL12 plays a role in the pathogenesis of preeclampsia. Further understanding of the regulatory mechanisms of CXCL12-mediated signaling in trophoblast functions and placental angiogenesis may help to design novel therapeutic approaches for preg- nancy-associated diseases.

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期刊信息
  • 《生物化学与生物物理学报:英文版》
  • 北大核心期刊(2004版)
  • 主管单位:
  • 主办单位:中国科学院上海生物化学研究所
  • 主编:
  • 地址:上海岳阳路319号
  • 邮编:200031
  • 邮箱:abbs@sibs.ac.cn
  • 电话:021-54920956 54920955
  • 国际标准刊号:ISSN:1672-9145
  • 国内统一刊号:ISSN:31-1940/Q
  • 邮发代号:4-210
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,荷兰文摘与引文数据库,美国生物医学检索系统,美国剑桥科学文摘,美国科学引文索引(扩展库),美国生物科学数据库,英国动物学记录,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),英国英国皇家化学学会文摘,中国北大核心期刊(2000版)
  • 被引量:5851