欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
白细胞衍生趋化因子2（leukocyte cell-derived chemotaxin-2,LECT2）属于肽酶M23家族,是具有趋化作用的蛋白质。LECT2能趋化免疫细胞吞噬病原微生物,抑制癌细胞的迁移,对多种疾病如肝癌、败血症、动脉粥样硬化均有重要作用。为了深入了解LECT2在疾病中的作用机制,本文对LECT2基因和蛋白质的结构、与间质表皮转化因子（mesenchymal epithelial transition factor,MET）、C型凝集素等受体的识别机制,在β-联蛋白、Wnt等信号通路中的调节作用,以及与多种疾病的关系进行综述。
英文摘要：
Leukocyte-derived chemotaxin-2（ LECT2） is a chemotactic protein belonging to the peptidase M23 family. As a chemotaxis for the immune cell to phagocytize pathogens,it can inhibit cancer cell migration and plays an important role in the immunological regulation of a variety of diseases such as liver cancer,sepsis and atherosclerosis. In order to understand the role of LECT2 in these diseases,here we illustrate the sequences and structure of the LECT2 protein,the mechanism to recognize its receptors including mesenchymal epithelial transition factor（ MET） and C-type lectin,as well as its regulatory role in the β-catenin and Wnt signaling pathway.
同期刊论文项目
同项目期刊论文
Identification and characterization of a novel IkappaB-epsilon-like gene from lamprey (Lampetra japo
Identification and characterization of a novel IκB-？-like gene from Lamprey (Lampetra japonica) with
Cell secretion from the adult lampreysupraneural body tissues possesses cytocidal activity against t
A novel member of lymphocyte-specific protein tyrosine kinase protein identified in lamprey, Lampetr
Cloning and expression analysis of a novel high - mobility group box 2 homologue from Lampetra japon
High-mobility-group family genes from Lampetra japonica reveal their early origin and molecular evol
期刊信息
位置：