中文摘要：

目的：通过探讨舌上皮细胞凋亡率，分析柴胡疏肝散加减干预围绝经期综合征舌象变化的机制。方法：选取同绝经期综合征患者60例，分为肾阴虚（30例）、肾阴阳两虚（30例），选择健康妇女30例为正常组，柴胡疏肝散加减治疗用绝经期综合征2个疗程，7天为1个疗程，采用流式细胞仪检测各组舌上皮细胞凋亡率。结果：围绝经期综合征患者舌上皮细胞凋亡率高于正常人（P〈0．05，P〈0．01），肾阴虚、肾阴阳两虚患者治疗后舌上皮细胞凋亡率低于治疗前（P〈0．05）。结论：柴胡疏肝散加减能有效降低同绝经期综合征的舌上皮细胞凋亡率。

英文摘要：

Objective： To explore the tongue epithelial cell apoptosis quantitatively to analysis tongue demonstration change mechanism of perimenopausal syndrome by Chaihu Shugan Decoction. Methods： Patients with perimenopausal syndrome 60 cases, divided into kidney yin deficiency （30 cases）, deficiency of both kidney yin and yang （30 cases）, 30 healthy cases in normal group. The treatment course lasted for 2 months. The flow cytometry was used to detect the tongue epithelial cell apoptosis. Results： The tongue epithelial cell apoptosis rate of perimenopausal syndrome patients was higher than that in the normal group （P〈0.05, P〈0.01）. After treatment, tongue epithelial cell apoptosis had a significant reduction （P〈0.05）. Conclusion： Chaihu Shugan Decoction can obviously reduce the rate of epithelial cell apoptosis of the perimenopausal syndrome tongue effectively.