中文摘要：

目的：探讨雌激素受体β基因（ERβ）多态性（rs3020444）与围绝经期综合征肝气郁结证（气郁证）的关系。方法：选择围绝经期综合征气郁证患者100例、非气郁证86例和正常对照组100例,应用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）法检测ERβ-T/C多态性。结果：卡方分割显示气郁证组的TT频率（84.0%）高于与非气郁证组（68.6%）及对照组（68.0%）,差异显著（P=0.004）;气郁证组T等位基因频率（91.0%）高于与非气郁证组（83.1%）及对照组（82.5%）,差异显著（P=0.008）;Logistic回归分析,以非气郁证组为参照系,调整混杂因素后TT基因型患气郁证的相对危险度为2.222（95%可信区间：1.172-4.744,P=0.015）。结论：ERβ-TT基因型可能是围绝经期综合征气郁证发病的易感因素之一。

英文摘要：

Objective：To investigate the association between polymorphisms of estrogen receptor β （ERβ） gene （rs3020444） and perimenopausal syndrome （PS） in patients with liver qi stagnation syndrome （LQSS）. Metheds：The ERβT/C genotype in 100 patients of PS of LQSS type （PS-LQSS group）,86 patients of PS of non-LSDS type （PS-non-LQSS group） and 100 healthy subjects （control） was determined by polymerase chain reaction and restriction fragment length polymorphism （PCR-RFLP） assay. Results：Partitions of χ^2 method showed that the higher prevalence of ERβ-TT genotypes was noted in PS-LQSS group （χ^2=8.307,P=0.004）,and the higher prevalence of T alleles was noted in PS-LQSS group （χ^2=7.129,P=0.008）. and Multinomial logistic-regression indicated that the odds ratios （OR） of the ERβ-TT genotypes vs TC/CC for PS-LQSS was 2.222 （95%CI：1.172-4.744,P=0.015） after adjusting for common miscellaneous factors. Conclusions：It was suggested that ERβ-TT genotypes was significantly associated with PS-LQSS,and ESRβ-TT may be one of the genes that contribute to PS-LQSS.