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中文摘要：
选取太湖流域（常州、无锡、镇江3市）为研究区,对其地下水、土壤、农作物等经口介质中邻苯二甲酸酯（PAEs）含量进行实验室检测,并通过体外实验（in vitro test）方法模拟不同介质PAEs对人体的生物有效性,同时考虑不同烹饪方式的PAEs消解规律,运用美国EPA推荐的暴露评价模型在对流域人群暴露参数优化的基础上推导流域人群暴露剂量.结果表明,流域内各经口介质中除部分蔬菜种类外PAEs均有不同程度的检出,水、土壤、主食、蔬菜4大类经口介质人体PAEs生物有效性范围为11.0%—78.5%,且不同单体差别较大.经不同烹饪方式后主食、蔬菜的PAEs残留量比例为60.7%—72.1%.结合前期暴露参数优化结果,考虑综合方式后人群!PAEs经口暴露剂量为1.59×10-1mg·kg-1·d-1,且男性低于女性,春、冬季节低于夏、秋季节,与国内外已有的报道相比均较高.
英文摘要：
Taihu Lake Basin （Changzhou, Wuxi, Zhenjiang） was selected as the study area. The concentrations of PAEs in groundwater, soil, crops and other oral media were detected, and the human bioaccessibility of PAEs in different media was measured by in vitro test. Considering the human bioaccessibility of PAEs and digestion law of PAEs in different cooking ways, the exposure dose was calculated using the measured exposure parameters through exposure risk assessment model of US EPA. The results showed that PAEs were detected in the oral media except some types of vegetables in Taihu Lake Basin. The bioaccessibility of PAEs in water, soil, staple foods, vegetables ranged from 11.0% to 78.5%, with significant differences for different PAE types. After treated with different cooking methods, the rates of remaining PAEs in staple foods and vegetables were 60.7% to 72.1%. Combined with the optimized exposure parameters and integrated manners, the average oral exposure dose was 1.59 × 10- 1mg. kg-1. d- 1 The exposure doses for men were lower than women, and the values in spring and winter were lower than summer and autumn. The doses were higher than those reported in foreign countries.
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