中文摘要：

随着分子生物学技术的不断发展,基因治疗在心血管疾病中的应用日益广泛,但无论是基因的直接注入还是以质粒和腺病毒作为载体均存在转染率低及安全性方面的问题.已有研究证实超声靶向破坏微泡可实现基因在心肌组织的靶向释放,提高转染率,增强治疗效果.本文就超声靶向破坏微泡介导基因传输在心血管疾病中的研究进展做一综述.

英文摘要：

With rapid development of techniques in molecular biology, gene therapy provides an efficient approach for treatment of cardiovascular disease. But the transfection rate is low and the safety is always an issue, regardless of whether the therapeutic gene was injected to the target directly or with the help of naked plasmid and adenovirus. Ultrasound - targeted micro- bubble destruction （UTMD） technique has become a potential strategy for target - specific gene delivery by facilitating uptake of the released gene into tissue and cell. Research has suggested that it could improve the transfection rate and the treatment effect. Herein, we discussed the research progress in gene therapy mediated by ultrasound -targeted microbubble destruction in cardio- vascular disease in this article.