中文摘要：

目的：研究角膜移植后角膜新生淋巴管与新生血管和炎症的关联。方法：人角膜取自行二次角膜移植的患者19例。淋巴内皮细胞受体（lymphatic vessel endothelial hyaluronan receptor,LYVE-1）和内皮细胞黏附因子-1（platelet endothelial celladhesion modecule-1,PECAM-1）双重免疫组化法标记角膜中的新生血管和淋巴管,进行淋巴管计数（lymphatic ves-sels counting,LVC）和血管计数（blood vessels counting,BVC）,比较BVC、炎症指数（inflammation index,IF）、移植历史（transplantation history,TH）与LVC之间的关联。结果：角膜移植后BVC,IF与LVC间均呈显著性正相关,而TH与LVC间呈显著性负相关。角膜移植后新生淋巴管、血管、眼表炎症间大致成平行发展,新生淋巴管最先退化,其次是眼表炎症,新生血管最后消退。结论：人角膜移植后角膜新生淋巴管与新生血管、眼表炎症之间存在着极为密切的关联。

英文摘要：

·AIM：To discuss the association of corneal hemangio-genesis,corneal inflammation with corneal lymphangio-genesis after human corneal transplantation.·METHODS：Nineteen human corneas were obtained from 19 patients undergoing a second corneal transplan-tation from 2005 to 2008.Corneal hemangiogenesis and lymphangiogenesis were examined by lymphatic vessel endothelial hyaluroman receptor（LYVE-1）and platelet endothelial cell adhesion modecule-1（PECAM-1）double immunohisto-chemistry.The state of corneal inflamma-tion was evaluat-ed by inflammation index（IF）grading.Then,the association of blood vessel counting（BVC）,IF,corneal transplantation history（TH）with lymphatic vessel count-ing（LVC）was examined.·RESULTS：LVC was strongly and positively correlated with both BVC（r=0.725;P〈0.01）and IF（r=0.661;P〈0.01）in transplanted human corneas.However,LVC was significantly and inversely correlated with TH（r=-0.301;P〈0.01）.Although the development of corneal lymphangio-genesis,hemangiogenesis and inflammation was parallel in general,corneal lymphangiogenesis disappeared followed by the inflammation of corneas and corneal blood vessels.·CONCLUSION：Corneal lymphangiogenesis correlates closely with corneal hemangiogenesis and inflammation after human corneal transplantation.·