中文摘要：

为了充分利用人参资源，寻找新型高效低毒的抗肿瘤药物，我们采用肿瘤细胞染色计数法（MTT法）比较了三种新的人参二醇脂肪酸酯衍生物[3β-乙酰氧基人参二醇（Ⅰ）、3β-棕榈酸酰氧基人参二醇（Ⅱ）、3β-硬脂酸酰氧基人参二醇（Ⅲ）]和人参二醇的抗肿瘤活性。所用癌株为绿猴肾癌株（Vero）；阳性对照为5-氟尿嘧啶；空白对照是5％新生牛血清的RPM11640培养基；阴性对照为与配药所用相同比例的溶剂和培养基。结果：化合物Ⅰ抗肿瘤活性最强，其次为人参二醇，Ⅱ和Ⅲ抗肿瘤活性最弱且两者活性相当；人参二醇脂肪酸酯衍生物抗肿瘤活性与浓度呈正相关，但与脂肪酸分子量无关。

英文摘要：

For making use of Ginseng resources and finding new anti-tumor drugs, the anti-tumor activity of three kinds of new panaxadiol fatty acid ester derivates： 3β-acetoxy panaxadiol （ Ⅰ ）,3β-paImitlc acid aceloxy panaxadio[ （Ⅱ ） ,3β-octadecanoic acid aceloxy panaxadiol（Ⅲ ） and panaxaiol were compared through the method of cell stain and counting. Tumor cell was Vero cell line. Positive control was 5-FU. Blank was RPMI1640 culture medium. Negative control was RPMI1640 culture medium and the solvent for subjected drugs. The result showed that compound I had the strongest anti-tumor activity, second was panaxadiol, Ⅱ and Ⅲ had the same and the weakest antitumor activity. Furthermore, the anti-tumor activities of panaxadiol fatty acid ester derivates showed positive correlation with subjects＇ concentrations, but no relationship with molecular weight of fatty acid.