中文摘要：

为了找到合适的^123Ⅰ标记的脑内β淀粉样蛋白（Aβ）斑块的显像剂，根据文献资料，合成了2-（4＇-二甲基氨基苯基）-6-三正丁基锡咪唑并[1，2-α]吡啶（IMPY），并采用双氧水标记法进行了^131Ⅰ标记，得到标记物^131Ⅰ-IMPY，放射化学纯度大于95％。方法对合成原料和条件作了相应的改进，提高了合成的收率。正常小鼠体内分布试验表明，在注射^131Ⅰ-IMPY后2min和60min，小鼠脑摄取率分别为（7．374±4．797）％／g和（0．967士0．409）％／g。说明^131Ⅰ-IMPY在小鼠脑中初始摄取很高，清除很快。^131Ⅰ-IMPY可能是一个很有发展潜力的Aβ斑块SPECT显像剂。

英文摘要：

The synthesis and biodistribution of β-amyloid plaques imaging agent [^131 Ⅰ]-2-（4＇-dimethylaminophenyl）-6-iodoimidazo[-1, 2-α] pyridine （^131Ⅰ-IMPY） is reported. The chemical structure of the precursor compound 2-（4＇-dimethylaminophenyl）-6-（tributylstanny） imidazo [1, 2-α] pyridine and all other intermediates are verified by IR, ^1H NMR and MS. The radioiodinated compound is prepared using iododestannylation reaction by hydrogen peroxide. The radiochemical purity of the final product is above 95% as determined by TLC. The in vivo biodistribution of [^131Ⅰ] IMPY in normal mice shows that excellent brain uptake and washout, indicating this thioflavin-T based small molecular probe has potential for in vivo imaging amyloid deposits.