中文摘要：

通过碘-131标记白藜芦醇探讨白藜芦醇在小鼠体内的分布代谢。采用过氧化物酶法对白藜芦醇进行131^I标记；经乙酸乙酯萃取纯化，以聚酰胺薄膜为支持介质，V（三氯甲烷）：V（丙酮）：V（乙醇）：V（水）=4：4：0．5：0．4为展开剂，测定标记物的标记率和放化纯；KM小鼠尾静脉注射131^I-白藜芦醇（每只0．185MBq，n=5）。131^I-白藜芦醇标记率达69．3％，萃取分离后其放化纯为95．9％，3、7和15d后分别为92．0％、90．4％、90．1％；动物实验显示，131^I-白藜芦醇在小鼠体内广泛分布，主要经肝和肾进行代谢，5min时每克组织百分注射剂量率（％ID·g^-1）分别为16．35、13．05，在肠中也有较高分布，10min时％ID·g^-1为11．70；甲状腺的摄取率随时间的延长而增加。碘标白藜芦醇标记物较稳定，可用于进一步的微量示踪研究。

英文摘要：

In order to investigate the preparation of radioiodinated resveratrol and its biodistribution in mice, resveratrol was labeled with 131^I using lactoperoxidase methods and purified by ethyl acetate. The radiolabeled compound was characterized by polyamide TLC, in which the substratum of Vtrichoromethane： Vaacetone： Vetbanol ： VAdam＇s ale ： 4 ： 4 ： 0. 5 ： 0. 4 was used as the developing agent. Biodistribution studies were accomplished on KM mice. At different time after radiopharmaceutical i. v. administration （0. 185 MBq 131^I-tetrahydropalmatine/mouse）, the animals were sacrificed （n=5 animals for each time）. Blood and the interested tissues were collected, washed, weighted and counted. The percent injected dose per gram （%ID · g^-1） was calculated for each sample. The labeling yield of 131^I-resveratrol is 69.3% and its RCPs are 95.9%, 92.0%, 90.4%, and 90. 1% after 1, 3, 7 and 15 d, respectively. Biodistribution in mice demonstrates that131^Iresveratrol is distributed into broad organs and tissues. However, it reveals higher levels in liver, kidney and intestine than in other tissues. In liver and kidney, the % ID · g ^-1are 16. 35% and 13. 05% at 5 min, respectively. 131^I-resveratrol is metabolized mainly through liver and kidney. Simultaneously, its high distribution is also found in intestine. The %ID · g^-1of 131^I-resveratrol is 11. 700% at 10 min; the activity in thyroid increases with time. Therefore, the 131^ I-resveratrol is worthy of further investigation to trace the compound in vivo and ex vivo.