中文摘要：

目的：研究11-羰基-β-乙酰乳香酸（AKBA）的抗氧化作用及胃保护效果.方法：30只SD大鼠随机分为5组：正常组（生理盐水5 mL/kg）,模型组（吲哚美辛48 mg/kg）,西咪替丁组（100 mg/kg）,低剂量AKBA组（100 mg/kg）,高剂量AKBA组（200mg/kg）.预给药1小时后,用吲哚美辛（48mg/kg）灌胃造模,评价溃疡指数（UI）、胃内容物酸度（pH）、胃壁黏液量（GWM）、前列腺素E2（PGE-2）及一氧化氮（NO）的含量,并检测超氧化物歧化酶（SOD）、过氧化氢酶（CAT）的活性,丙二醛（MDA）含量及核转录相关因子2（Nrt2）和血红素加氧酶1（HO-1）的表达量.结果：①与造模组相比,AKBA高剂量组（P＜0.05）与西咪替丁组（P＜0.001）显著降低了吲哚美辛诱导的胃粘膜损伤,AKBA低剂量组的差异无统计学意义;②AKBA与西咪替丁均显著升高胃内容物pH（P＜0.001）（AKBA低剂量组P＜0.05）,增加GWM含量（P＜0.001）;③与造模组相比,AKBA及西咪替丁组均显著增高PGE-2及NO含量（P＜0.001）;④与造模组相比,AKBA及西咪替丁组均显著增高SOD活性（P＜0.001）（AKBA低剂量组P＜0.05）及CAT活性（P＜0.001）并降低了MDA含量（P＜0.001）;⑤与造模组相比,AKBA高剂量组及西咪替丁组促进Nrf2及HO-1表达明显增高（P＜0.05）.结论：AKBA有较好的胃保护效果,同时可以通过升高GWM、降低胃内容物pH,升高NO含量,阻止PGE-2的降低,同时恢复SOD、CAT的活性,降低MDA含量,促进Nrt2及HO-1的表达发挥胃黏膜保护的作用.

英文摘要：

Objective：To investigate the protective effect and antioxidant effect of Acetyl-11-Keto-beta-Boswellic Acid （AKBA） in gastric injury in rats.Methods：All the 30 rats were divided evenly and randomly into the following 5 groups：control group （5 mL/kg physiological saline）,model group （5 mL/kg physiological saline）,cimetidine group （100 mg/kg）,L-AKBA group （100 mg/kg） and H-AKBA group （200 mg/kg）.One hour before administration of indomethacin,the vehicle,cimetidine and AKBA were given to each experimental group through administration by gavage.The gastro-protection effect was assessed by measuring ulcer index （UI）,gastric juice acidity （pH）,gastric wall mucus （GWM）,prostaglandin E2 （PGE-2） and nitric oxide （NO）.The antioxidant effects were measured through the activity of superoxide dismutase （SOD）,catalase （CAT） and the level of MDA.Meanwhile,the expression of Erythroid-2-related factor 2 （Nrf2） and heme oxygenase-1 （HO-1） were assessed.Results：① Compared with model group,UI was decreased significantly in H-AKBA group （P＜0.05） and cimetidine group （P＜0.001）,while the difference between L-AKBA group and model group were not statistical significance;② Compared with model group,and the GWM were increased markedly in both AKBA groups and cimetidine group （P＜0.001）,and pH were increased in H-AKBA group,cimetidine group （P＜0.001） and L-AKBA group （P＜0.05）;③ Compared with control group,the level of PGE-2 and NO were significantly increased in both AKBA groups and cimetidine group （P ＜0.001）.④ Compared with model group,the activity of SOD and CAT were increased in H-AKBA group,cimetidine group （P＜0.001）,and in L-AKBA group （P＜0.05）.Besides,the level of MDA were decreased in both AKBA groups and cimetidine group （P＜0.001）.⑤ The expression of Nrf2 and HO-1 were increased in H-AKBA group,cimetidine group （P＜0.05）.Conclusions：The AKBA could protect gastric from injury through increasing GW