中文摘要：

Kallistatin是一种丝氨酸蛋白酶抑制剂.早期研究发现,它能与组织激肽释放酶结合并抑制其活性,随后kallistatin的抗血管生成、抗炎、抗肿瘤、抗氧化等功能也逐步被发现.Kallistatin有2个主要功能结构域：反应中心环和肝素结合结构域,各自发挥不同的作用.Kallistatin通过肝素结合结构域竞争性抑制血管内皮生长因子（VEGF）和肿瘤坏死因子与它们的受体结合,进而起到抗血管生成和抗炎作用.近年研究发现,kallistatin的多种功能由不同信号通路介导,主要为PI3K-Akt信号通路和TNF-α-NF-κB信号通路.此外,kallistatin还通过丝裂原活化激酶（mitogen-activated protein kinase,MAPK）等信号通路发挥作用.本文就目前研究的kallistatin的结构功能及其在PI3K-Akt、TNF-α等多种信号通路中的调节功能和作用机制进行阐述.

英文摘要：

Kallistatin is a unique serine proteinase inhibitor（serpin） isolated from normal human serum as a kallikrein-binding protein.Recent studies showed that kallistatin is of multiple biologic functions besides binding tissue kallikrein in anti-angiogenesis,protection against inflammation,anti-cancer,oxidation resistance.As a heparin-binding serpin,the structures related to these activities involve a reactive center loop（RCL） and the heparin binding domain,which competes the bonding of vascular endothelial growth factor（VEGF） and tumor necrosis factor-α（TNF-α） binding to their receptors for anti-angiogenesis and anti-inflammation activities.Various signaling pathways contribute to kallistatin functions,including primarily the PI3K-Akt and TNF-α-NF-κB signal pathway,as well as the MAPK（mitogen-activated protein kinase） and other pathways.In this review,the molecular structure and biological activities of kallistatin is overviewed,the regulation and mechanism of kallistatin signaling pathways are also discussed.