中文摘要：

目的研究菊科蟛蜞菊属植物蟛蜞菊的化学成分。方法蟛蜞菊全草粉碎后用95%乙醇提取,提取物分别经过石油醚、乙酸乙酯和正丁醇萃取,石油醚部分采用硅胶柱层析、葡聚糖凝胶、反复重结晶、制备型HPLC等多种技术分离纯化,通过理化性质和波谱数据鉴定所得化合物的化学结构。结果从蟛蜞菊中分离得到12个化合物,分别鉴定为ent-kaura-9（11）,16-en-19-oic acid（1）,ent-kaura-16-en-19-oic acid（2）,15β,16β-epoxy-17-hydroxy-ent-kauran-19-oic acid（3）,16α,17-dihydroxy-ent-kauran-19-oic acid（4）,16α-hydroxy-ent-kauran-19-oic acid（5）,15α-hydroxy-entkaura-16-en-19-oic acid（6）,3α-angeloyloxy-9β-hydroxy-ent-kaura-16-en-19-oic acid（7）,3α-cinnamoyloxy-9β-hydroxy-entkaura-16-en-19-oic acid（8）,3α-cinnamoyloxy-17-hydroxy-ent-kaura-15-en-19-oic acid（9）,12α-methoxy-ent-kaura-9（11）,16-en-19-oic acid（10）,ent-12-oxokaur-9（11）,16-en-19-oic acid（11）,17-hydroxy-ent-kaura-15-en-19-oic acid（12）。结论化合物3～9为首次从该植物中分离得到,化合物10～12为首次从该属中分离得到。

英文摘要：

AIM To investigate the chemical constituents from Wedelia chinensis. METHODS The dried palnt materials were powdered and extracted with 95% EtOH,then partitioned with petroleum ether,EtOAc,and n-BuOH. The petroleum ether fraction was subjected to silica gel,Sephdex-HL20,recrystallization and preparative HPLC. The structures were identified by physicochemical properties and spectroscopic methods. RESULTS Twelve compounds were respectively identified as ent-kaura-9（ 11）,16-en-19-oic acid（ 1）,ent-kaura-16-en-19-oic acid（ 2）,15β,16β-epoxy-17-hydroxy-ent-kauran- 19-oic acid（ 3）,16α,17-dihydroxy-ent-kauran-19-oic acid（ 4）,16α-hydroxy-ent-kauran-19-oic acid（ 5）,15α- hydroxy-ent-kaura-16-en-19-oic acid（ 6）,3α-angeloyloxy-9β-hydroxy-ent-kaura-16-en-19-oic acid（ 7）,3α-cinnamoyloxy-9β-hydroxy-ent-kaura-16-en-19-oic acid（ 8）, 3α-cinnamoyloxy-17-hydroxy-ent-kaura-15-en-19-oic acid（ 9）,12α- methoxy-ent-kaura-9（ 11）,16-en-19-oic acid（ 10）,ent-12-oxokaur-9（ 11）,16-en-19-oic acid（ 11）,17- hydroxy-ent- kaura-15-en-19-oic acid（ 12）. CONCLUSION Compounds 3- 9 are isolated from this plant for the first time. Compounds 10- 12 are obtained from the genus Wedelia for the first time.