目的:综述针灸联合止吐剂防治化疗相关性恶心呕吐的临床研究进展,并提出导致国内外研究结论差异的可能原因。方法:检索中国期刊全文数据库(CNKI)、万方数据知识服务平台(WANFANG DATA)、Pubmed中2009-2015年的相关文献。中文检索词为"针灸""化疗""恶心""呕吐",英文检索词为"Acupuncture-moxibustion""Chemotherapy""Nausea""Vomiting"。纳入符合标准的文献,排除重复性研究和部分低质量文献。结果与结论:共纳入34篇文献,其中英文文献13篇,中文文献21篇。针刺、艾灸、电针、耳穴贴压、穴位注射等方法都能够有效改善化疗后恶心、呕吐症状,降低常规止吐剂的毒副作用,提高患者生活质量,并且操作方法简单、价格低廉,值得临床推广应用。但针灸防治化疗相关性恶心呕吐国内外研究结论存在差异,国外一些研究并不能肯定针灸防治化疗相关性恶心呕吐的疗效,甚至得出完全相反的结论。
Objective:To review the clinical research progress on acupuncture-moxibustion combined with anti-nausea drug prevention and treatment of chemotherapy-induced nausea and vomiting,and propose possible reasons for the differences between domestic and international research findings.Methods:We searched CNKI,WANFANG DATA,Pubmed for relevant articles published from2009 to 2015using key words of " Acupuncture-moxibustion" " Chemotherapy" " Nausea" " Vomiting" in Chinese and English.Repetitive studies and some low-quality literature were excluded according to the inclusion and exclusion criteria.Results and Conclusion:Finally 34 articles were included,including 21 Chinese publications and 13 English ones.Acupuncture,moxibustion,electric acupuncture,auricular application,point injection and other methods can effectively improve symptoms of nausea and vomiting after chemotherapy,reduce the side effects of conventional antiemetic,improve patients' life quality,and the operation method is simple,low cost,it is worthy of clinical popularization and application.But the research conclusions between domestic and international differs,the therapeutic effect of acupuncture-moxibustion on chemotherapy-related nausea and vomiting cannot be determined at present according to some international studies,some evidence abroad even points to the opposite conclusion.