中文摘要：

目的建立脑卒中后抑郁（PSD）动物模型并评价西酞普兰干预作用。方法大脑中动脉阻塞法建立局灶脑缺血模型，加用慢性不可预见温和应激结合孤养，建立PSD大鼠模型并予以西酞普兰干预。结果CMS开始后第19天，模型大鼠水平活动得分（与基线、正常、卒中组相比均P〈0．001；与应激抑郁组相比均P〈0．01），垂直活动得分（与基线、正常、卒中组相比均P〈0．001；与应激抑郁组相比均P〈0．05）显著降低。19～42d，模型组大鼠水平得分（从37．8±1．7至34．2±1．2）和垂直得分（从9．7±0．8至7．8±0．8）显示与应激抑郁组水平得分（从41．0±1．3至42．3±0．8）、垂直得分（从11．2±0．4至11．7±0．8）程度不同的进行性下降趋势。第3～6周蔗糖水饮用比例显著少于基线及各组（均P〈0．001）。结论模型大鼠充分并持续表现快感缺乏等PSD核心症状．可操作性和重复性较好，是研究PSD的理想模型。西酞普兰能改善PSD大鼠行为学异常。

英文摘要：

Objective To establish an animal model of post-stroke depression （PSD） and assess the effects of citalopram on PSD. Methods Fifty-two male SD rats were randomly divided into 3 groups. Normal group （ n = 6） underwent sham operation. Chronic unpredictable mild stress （CMS） group （ n = 6 ）, underwent separate raising and CMS. Middle cerebral artery occlusion （MCAO） group （n = 24） underwent MCAO and then re-divided into 3 equal subgroups： stroke subgroup, PSD model subgroup （undergoing isolated raising and CMS so as to establish PSD models ）, and citalopram subgroup （treated with intraperituneal injection of citalopram, a selective serotonin reuptake inhibitor for 6 weeks）. The rats were examined dynamically at the 19th, 28th, and 42nd days after CMS by open-field test （OFT） and sucrose consumption test. Results On the 19th day after CMS the locomotor activity score of the PSD models was significantly lower （ P 〈0. 001 compared to the baseline level of the same subgroup and to those of the control and stroke rats, P 〈 0.01 compared to the CMS group） ; and the frequency of rearing score of the PSD models was significantly decreased （P 〈 0. 001 compared to its baseline level and to those of the control and stroke groups, and P 〈 0. 05 compared to the CMS group）. During the days 19-42, the frequency of locomotor and exploratory activities of the PSD model rats declined continually, from 37.8 ± 1.7 to 34. 2 ± 1.2 and from 9. 7 ± 0. 8 to 7.8 ± 0. 8 respectively, showing a tendency in just the reverse direction in the CMS group （from 41.0 ± 1.3 to 42. 3±0. 8 and from 11.2±0. 4 to 11.7±0. 8 respectively）. The PSD rats showed a reduction in sucrose preference at week 3 and afterwards （P 〈0. 001 compared with other groups）. The levels of open-field activities and proportion of rats with sucrose preference in the citalopram subgroup were all significantly higher than those in other groups （ all P 〈 0. 001 ） . Conclusion Anhedonia and underaetivity, t