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中文摘要：
钙/钙调蛋白依赖性蛋白激酶Ⅱ（Ca2 ＋/calmodulin-dependent protein kinaseⅡ,CaMKⅡ）是一种主要表达于心脏的多功能丝氨酸/苏氨酸蛋白激酶,通过磷酸化和氧化调节心肌细胞的活性,广泛参与心血管系统生理活动及病理变化的信号转导,与多种心血管疾病密切相关.新近研究表明,活性氧簇激活的CaMKⅡ在许多心血管疾病的发生发展中发挥关键作用,包括心律失常、缺血性心脏病、心肌肥大以及心力衰竭等.对氧化CaMKⅡ信号系统的研究可为临床心血管疾病的治疗提供重要策略和潜在靶点.
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