中文摘要：

目的探讨年轻人群甲型H1N1病毒感染排毒规律。方法收集2009年10月-2010年1月医院就诊的67例甲型H1N1患者临床资料,对患者每天进行连续咽拭子采样,采用实时荧光定量PCR法检测甲型H1N1病毒,进而对两组患者临床特征、病毒排出规律进行分析;同期37例季节性流感患者作为对照。结果 H1N1组患者中82.1%出现发热症状,但高热发生率（7.5%）明显低于季节性流感组（21.6%）,差异有统计学意义（P〈0.05）;H1N1组患者平均排毒天数为（6.390±1.466）d,但自发病之日起7 d仍有31.3%患者排出病毒;退热后平均排毒天数为（4.51±1.79）d,3.0%患者退热后7 d仍有病毒排出。结论年轻人群甲型H1N1病毒感染后临床症状与季节性流感相似,但自发病之日起7 d仍有31.3%患者排出病毒,这提示感染后经验性隔离7 d尚存在传播风险,应考虑适当延长;日常生活接触传播在所观察的轻症年轻人群中可能性较小。

英文摘要：

OBJECTIVE To explore viral shedding profile of H1N1 influenza in Chinese young adults.METHODS From Oct 2009 to Jan 2010,a total of 67 patients without underlying diseases aged from 18 to 35 years old were collected.The pharynx swab of the patients were collected everyday and detected by Real Time RT-PCR.The clinical features,viral shedding profile were analyzed.37 patients with seasonal influenza were observed as control.RESULTS Among the patients with H1N1 virus infection,82.1% patients presented with fever symptom,but more patients with high fever ≥39℃ were found in seasonal influenza patients（P0.05）.The average duration of viral shedding in H1N1 influenza group was 6.39±1.466 4-10d.But viral shedding was still found in 31.3% patients after 7 days following illness onset.The average duration of viral shedding after temperature returned normal were 4.51±1.79,and 3.0% patients were found to be viral shedding 7 days later after normalization of body temperature.CONCLUSIONS The clinical features of H1N1 influenza in young people are similar to those of the seasonal influenza.It suggests the experienced isolation for 7 days are still at the risk of transmission,which should be considered to be prolonged.Transmission by the daily contact hardly occurred among the young people with mild symptoms.