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星形聚乳酸
  • 期刊名称:化学进展,2008,20(10):1578-1587(SCI收录)
  • 时间:0
  • 分类:O631.5[理学—高分子化学;理学—化学]
  • 作者机构:[1]华南师范大学化学与环境学院化学系,广州510006
  • 相关基金:国家自然科学基金项目(No.20772035)和广东省自然科学基金博士科研启动基金项目(No.5300082)资助
  • 相关项目:基于呋喃酮砌块的有机合成方法学研究
中文摘要:

星形聚乳酸以其独特的结构与性能引起了人们的广泛兴趣,通常使用“先核后臂”法进行合成。本文根据不同类型的“核”进行分类,如小分子多羟基醇(天然糖醇)、无机(杂环)化合物的衍生物、金属有机化合物、多元酚的衍生物和星形高分子等,综述了星形聚乳酸近年来合成(尤其是丙交酯开环聚合法合成)、性能与应用等方面的研究进展,指出星形聚乳酸高分子量、低黏度、良好溶解性和热稳定性等优点有利于其在药物缓释等生物医用材料中的加工应用。

英文摘要:

The star-shaped polylactic acids (SPLA) have received considerable attention due to their unique structure and good properties. Usually, SPLA are synthesized by the "core first" method, which classified by different "core" in SPLA, such as small molecular polyol (including natural sugar alcohols ), hydroxyl-terminated cyclotriphosphazene derivatives, derivatives, and some star-shaped hydroxyl-terminated metallic organic compounds, hydroxyl-terminated phenolic macroinitiators. The progress on their synthesis, especially via the ring-opening polymerization of lactide, properties and application are summarized. It is pointed out that the higher molecular weight and lower viscosity, better solubility and thermal properties made SPLA have more applications in biomedical materials (including drug delivery carrier) than linear polylactic acids (LPLA).

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