通过2-氨基-4-(4-甲氧基苯基)-5-(1H-1,2,4-二二唑-l-基)-1,3-噻唑与取代苯甲醛发生缩合,合成了-系列新型含二唑环的噻唑席大碱类化合物.利用^1HNMR和兀素分析对所有化合物进行了结构表征.初步的毒性试号令表明,部分标题化合物具有-定的抗肿瘤活性.
Reaction of 2-amino-4-(4-methoxyphenyl)-5-(1H-1,2,4-triazol- 1-yl)-1,3-thiazole with various substituted benzal- dehydes produced a series of novel thiazole Schiff bases containing 1H-1,2,4-triazole ring. Their structures were characterized by ^1H NMR spectra and elemental analysis. The bioassay data indicated that some of the title compounds showed certain anti- tumor activities.