中文摘要：

调查预防效果和 Kanggushu 的不同摘录的可能的位于在 ovariectomized 老鼠的骨质疏松症下面机制的目的() 在 \O 上。方法 100 并且 sixtyfive 女性 SD 老鼠被划分成 11 个组：控制，假冒，模型， Xianling Gubao 囊() ， nilestriol， Kanggushu 水的摘录高度 -- ，中等 -- ，并且低剂量并且板油摘录高度 -- ，中等 -- ，并且低剂量的组。骨质疏松症模型被 ovariectomizing 成为老鼠。分别地，当另外的 3 个组被管理时， 8 组织的后者与 Xianling Gubao 囊， nilestriol， Kanggushu 水的摘录和板油摘录 intragastricly 被管理 12 个星期口头上地盐。整个身体骨头矿物质密度，骨头矿物质内容，子宫的机关系数，浆液 estradiol 和碱的磷酸酶满足，血钙，磷， interleukin 6 并且在治疗以后的骨头 Gla 蛋白质层次被监视。另外，腿节的三点的弯曲测试，他染色，并且扫描电子显微镜被执行探索药效学和内在的机制。与模型组，的 ovariectomized 老鼠比较的结果 Kanggushu 水的摘录高剂量导致了增加的骨头矿物质密度，骨头矿物质内容和子宫，改进 estradiol 水平，和改进最大值的机关系数负担和结构的僵硬(P < 0.05 或 P < 0.01 ) 。二维、三维的 trabecular 结构也被观察在下面他在高剂量的组是的 Kanggushu 水的摘录染色并且扫描 trabecular 骨头的电子显微镜学，和数字和厚度显著地与模型组相比增加了，当在骨头髓洞的类脂化合物微滴是时显著地少些。然而，在血钙没有重要差别，全部的浆液在不同处理组之中的碱的磷酸酶和骨头 Gla 蛋白质。总的来说， Kanggushu 水的摘录的 osteoprotective 效果比得上 nilestriol 的那些并且是显著地比那些更有效 Xianling Gubao 囊。预防措施 Kanggushu 水的摘录完成的结论可能是部分由于增加的 estradiol 铺平，骨头 trabecular reticulate 结构的加速的恢复，和在骨质疏松症老鼠的因此增加

英文摘要：

Objective： To investigate the preventive effects and possible underlying mechanism of different extracts of Kanggushu （抗骨疏） on osteoporosis in ovariectomized rats. Methods： One hundred and sixty- five female SD rats were divided into 11 groups： control, sham, model, Xianling Gubao Capsule （仙灵骨葆胶囊）, nilestriol, Kanggushu aqueous extract high-, medium-, and low-dose and suet extract high-, medium-, and low-dose groups. The osteoporosis model was made by ovariectomizing the rats. The latter 8 groups were administered intragastricly with Xianling Gubao Capsule, nilestriol, Kanggushu aqueous extract and suet extract for 12 weeks, respectively, while the other 3 groups were administered orally saline. The whole body bone mineral density, bone mineral content, organ coefficient of uterus, serum estradiol and alkaline phosphatase contents, blood calcium, phosphorus, interleukin 6 and bone Gla-protein levels after treatment were monitored. Additionally, three-point bending test of femur, HE staining, and scanning electron microscope were performed to explore the pharmacodynamics and underlying mechanisms. Results： In comparison with ovariectomized rats of model group, Kanggushu aqueous extract high-dose resulted in an increased bone mineral density, bone mineral content and organ coefficient of uterus, improved estradiol level, and improved maximum load and structural stiffness （P〈0.05 or P〈0.01）. Two-dimensional and thrae-dimensional trabecular structure was also observed under HE staining and scanning electron microscopy, and the number and thickness of trabecular bone in Kanggushu aqueous extract high-dose group was significantly increased compared to the model group, while the lipid droplets in bone marrow cavity were significantly less. However, there were no significant differences in blood calcium, total serum alkaline phosphatase and bone Gla protein among different treatment groups. Overall, the osteoprotective effects of Kanggushu aqueous extract were comparable to those