中文摘要：

腺病毒载体是基因治疗的常用载体之一，已经广泛应用于肿瘤和遗传疾病等的基因治疗研究中。但是临床发现腺病毒载体有较高的免疫原性，同时缺乏组织或细胞特异性，制约了其在临床上的应用。通过共价键结合或者静电力作用，将高分子修饰到病毒衣壳上，利用高分子的特殊性质可以降低载体的免疫原性和提高载体的靶向性，同时载体保持了较高的转染能力。主要综述了近年来采用高分子对腺病毒载体进行修饰的研究进展。

英文摘要：

Adenovirus is a kind of virus vector which is used widely in gene therapy, especially in treating cancer and heredopathia. However, its non-specificity and high immunogenicity have inhibited its application in clinical. Virus which modified with macromolecular to the eapsid of virus through covalently conjugate or electrostatic interaction have lower immunogenicity and high tropism, and the modifications have little effect in their gene transduction efficacy. It is becoming an important modification method in adenovirus. The progress of modified adenovirus with polymers were reviewed.