中文摘要：

目的 探讨多系统萎缩（MSA）-P型与帕金森病（PD）的临床特征和认知功能损害的异同。方法 连续选择MSA-P型和PD患者共55例,根据诊断分为MSA-P组19例和PD组36例。详细收集年龄、病程、教育年限、统一PD评分量表第3部分（UPDRS-Ⅲ）及日常生活活动能力量表（ADL）评分等,用简易智能状态检查量表（MMSE）、蒙特利尔认知评估量表（MoCA）、韦氏智力及记忆力等进行神经心理评估,并进行比较分析。结果 MSA-P组的ADL及UPDRS-Ⅲ评分均显著高于PD组[（31.74±10.56）分vs（16.39±4.18）分;（43.79±16.99）分vs（28.72±15.14）分,P〈0.05]。2组MMSE、MoCA总分比较,无统计学差异[（26.32±3.13）分vs（27.50±2.52）分;（20.42±5.00）分vs（22.56±4.80）分,P〉0.05]。MSA-P组操作量表分及韦氏记忆量表分低于PD组[（30.32±9.91）分vs（37.28±9.09）分;（54.53±23.14）分vs（76.28±22.97）分,P〈0.05];图形排列、积木测试和理解记忆评分低于PD组[（5.79±2.12）分vs（7.22±1.69）分;（6.16±3.06）分vs（8.17±2.78）分;（5.53±2.74）分vs（7.75±2.99）,P〈0.05]。结论 MSA-P型患者运动功能及日常生活能力恶化较PD快;其总体认知功能受损与PD类似,但执行功能、视空间和记忆力等的认知损害较PD严重。

英文摘要：

Objective To compare the cognitive functions of multiple system atrophy-parkinsonian variant （MSA P） and PD by studying their neuropsychological performances. Methods Fifty-five MSA P and PD patients were divided into MSA-P group （n=19） and PD group （n=36）. Their age,desease duration, education years, UPDRS -ⅢⅢ score, ADL score were recorded, their intelligence and memory were assessed according to the MMSE, MoCA scale, WAIS and WMS-R, and compared. Results The ADL and UPDRS HI scores were significantly higher in MSA P group than in PD group （31.74±10.56 vs 16.39±4.18,43.79±16.99 vs 28.72±15.14,P〈0.05）. No significant difference was found in MMSE and MoCA between the two groups （26.32±3. 13 vs 27.50±2.52,20.42±5.00 vs 22.56±4.80,P〉0.05）. The operation scale score,WMS-R score, block design score, picture arrangement score and logical memory score were significantly lower in MSA-P group than in PD group （P〈0.05）. Conclusion The motor function and daily life ability deteriorate faster in MSA-P patients than in PD patients. The general cognitive impairment is sim ilar in MSA P and PD patients. However,the impairment of executive function,visuospatial func tion and memory is more severe in MSA P patients than in PD patients.